GHS Classification Result

Chemical Name:N,N-Dimethylformamide
CAS:68-12-2

Result:
ID: 149
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is 58degC (c.c.) (ICSC, 2000) which is classified into Category 3. Classified into Class 3 and Packing Group III (UN#2265) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 445degC (ICSC, 2000)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#2265)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 3,370mg/kg calculated from the testing data of rat LD50 (oral route) of 4,200mg/kg (MOE Risk Assessment vol.1, 2002), 3,040mg/kg (SIDS (2004)), 3,000mg/kg, 3,920mg/kg, 4,000 mg/kg, 4,320mg/kg, 3,200mg/kg, 7,170mg/kg (EHC 114 (1991)).
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 4,390mg/kg, calculated from the testing data of rat LD50 (dermal route) of 11,140mg/kg, 11,000mg/kg (EHC 114 (1991)), and 3,500mg/kg (MOE Risk Assessment vol. 1 (2002)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Not classified - - - - Based on the evidence of "no irritation" from animal eye irritation tests (CERI-NITE Hazard Assessment No.8 (2005)). Accidental exposure to the substance caused skin irritation, according to some report.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in the report on rabbit eye irritation tests (EHC 114 (1991)): 75-100% solutions cause severe eye irritation; mild reddening of the conjunctiva and moderate corneal damage are observed within 14 days of exposure in the area, where severe damage, mild degeneration of the surface and arterialization are observed. The substance is thus considered "severely irritating" to the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Based on the description in the report on guinea pig skin sensitization tests (performed based on the maximization method) (EHC 114 (1991)) - Negative. However, classification is not possible, with only one set of data showing "negative" available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on negative data on multi-generation mutagenicity tests, the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.8 (2005).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC 71 (1999), Category A4 by ACGIH-TLV (2005).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in CERI-NITE Hazard Assessment No.8 (2005): Malformations (cleft palate, exencephalia, hydrocephalus, absence of sphenoid bone, fused ribs, absence of a tail, etc.) are observed in offspring at dose levels not toxic to parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (liver), Category 2 (respiratory system) Danger
Warning
H370: Causes damage to organs (liver)
H371: May cause damage to organs (respiratory system)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
Based on the human evidence including "eating disorder, vomiting, pains in the abdominal/pelvic/femoral regions, hepatic fibrosis and aggregated histiocytes (after the disappearance of the symptoms)" (CERI-NITE Hazard Assessment No.8 (2005)), and the evidence from animal studies including "hypertrophy of the walls of the alveoli (CERI-NITE Hazard Assessment No.8 (2005))" The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "hepatic function disorder, symptoms of alcohol intolerance (IRIS (1990)); hepatopathy, an increase in AST/ALT levels, focal hepatocyte necrosis, fatty degeneration of the microvesicles of the agranular endoplasmic reticulum. And based on the evidence from animal studies including: hypertrophy of centrolobular hepatocytes" (NTP TOX22 (1992)), "symptoms suggesting acute hepatocyte damage, an increase in SGPT/SGOT activity, histopathological changes in the liver of a young animal" (IRIS (1990)), "an increase in ALP activity" (over 100ppm), "an increase in ALT activity" (over 200ppm) "hepatocyte necrosis" (over 200ppm) (CERI-NITE Hazard Assessment No.8 (2005)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It was classified into Not classified from 96 hours LC50>100mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals (1995) and others.).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it was not water-insolubility (the water-solubility =1.00*106mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information