GHS Classification Result

Chemical Name：Tetrachloroethylene
CAS：127-18-4

Result：
ID: 155
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-combustible (ICSC, 2000)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing unsaturated bonds. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 6.1, UN#1897)
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC, 2000)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2000)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1897) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the testing data of rat LD50 (oral route) of 13,000mg/kg (EHC 31 (1984)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the testing data of mouse LD50 (dermal route) of 5,000mg/kg (IUCLID (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the LC50 value (4 hours) of 5,020ppm, calculated from the testing data of rat LC50 (4-hour inhalation of vapour) of 27.8mg/L (EHC 31 (1984)), was lower than 90% of the saturated vapour concentration (18,500ppm) under a saturated vapour pressure of 1.87kPa (20degC) (CERI Hazard Data 96-11 (1997)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on human epidemiological studies and rabbit skin irritation tests (CERI-NITE Hazard Assessment No.65 (2005)): Severe skin irritation associated with dermal necrosis is observed, although the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.65 (2005)): "moderate irritant."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests) described in CERI-NITE Hazard Assessment No. 65, 2005, ATSDR (1997).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2A by IARC (1995).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.65 (2005), ACGIH (7th, 2001), ATSDR (1997) and NICNAS (2001): Adverse effects are observed in the embryonic development of rats and mice.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system, liver), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, respiratory system, liver)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "nausea, belching, headache, dizziness, malaise, extreme exhaustion, physical weakness, sleepiness, perspiration, a decrease in blood pressure, severe rigor, areflexia, hypomyotonia, visual impairment, adverse effects on the central nervous system (shallow respiration, etc.), pulmonary edema" (CERI-NITE Hazard Assessment No.65 (2005)), and the evidence from animal studies including "hepatic fatty degeneration (EHC 31 (1984)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, respiratory system, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, respiratory system, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "a severe disorder of neuropsychological function (sensomobility, perception speed, cautiousness, memory, concentration, etc.), symptoms of autonomic disorder (pricking sense disorder, tingling sensation in the hands and feet, rheumatoid pain, staggering gait, etc.), changes in the personality structure (emotional instability, etc.)," "irregular defecation, constipation, diarrhea, decreased libido, alcohol intolerance, gait disorder, speech disorder, rigidity of the fingers, fever-related seizure, hepatopathy, cirrhosis, pulmonary edema, dyspnea" (CERI-NITE Hazard Assessment No.65 (2005)), and the evidence from animal studies including "nucleus hypertrophy of renal tubular epithelial cells, hepatocellular vacuolar degeneration and necrosis, inflammatory cellular infiltration, urinary cast, nephrosis," "diminished muscle tone, convulsions, restlessness, coma, areflexia, an increase in ALT levels, an increase in triglyceride concentrations, hepatic fatty degeneration, accumulation of BSP (bromo-sulfophthalein) (diminished renal excretion), tremor, depression of the central nervous system" (CERI-NITE Hazard Assessment No.65 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in ICSC (J) 2003: "Effects of short-term exposure - may cause chemical pneumonia if swallowed."

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.602mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=77.1(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 11%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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