GHS Classification Result

Chemical Name：Thiram
CAS：137-26-8

Result：
ID: 157
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though it has a flash point and "Flammable" (ICSC (J) (2000))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - It is based on the information (HSDB (2006)) that it has no corrosiveness in the state of dryness.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 value: 865 to 1300 mg/kg and 780 to 865 mg/kg (EHC 78, 1988), 400 to 4000 mg/kg (ACGIH 7th, 2001), 865mg/kg, and 375 to 1000 mg/kg and 1400 to 5400 mg/kg (IARC 53, 1991). Since the calculated values was 772.2mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - There are the statement that toxicity was not manifested and LD50 value was >2000mg/kg in the 2000mg/kg dermally administered test of rat (EHC 78, 1988, ACGIH 7th, 2001, IARC 53, 1991)Based on this statement, it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is description that rats survived even if they ware exposed to 0.5mg/L and 6.255mg/L for 4 hours (ACGIH (7th, 2001)). But there was no data on the lethal concentration, and category could not be specified. Therefore, it cannot classify since data is insufficient.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From the description that the skin of the rabbit is stimulated very slightly (ACGIH (7th, 2001)), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B from description that the eye of the rabbit of ACGIH (7th, 2001) is stimulated very slightly.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because EHC 78 (1988) and DFGOT vol.15 (2001) describe case reports of allergic contact dermatitis, DFGOT vol.15 (2001) describes that the Lympho node test (LLNA method) using mice results positive, and DFG classifies this into a skin sensitization.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1B. Because there are positive results in the chromosome aberration tests using mouse spermatogenic cells, which are in vivo mutagenicity tests using germ cells (IARC 53, 1991).
6 Carcinogenicity Not classified - - - - It is classified into a group 3 (IARC 53, 1991) according to IARC and was classified into A4 (ACGIH 7th, 2001) according to ACGIH. So it was set as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description that in inhalation exposure or oral administration examination using rats, reduced reproductive potential in male and female were observed with the dose occuring general toxicity (EHC 78 (1988) and IARC 53 (1991)). And although there is no description about general toxicity in parent animals, there is a description that the fetal malformation was observed in the art and mice pregnant administration examination. Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there was no report of a specific case, due to the description that the effect on paraesthesia, such as muscle cramp or paraesthesia, is admitted as acute toxicity to the human in EHC 78 (1988). So it was judged that it was not temporary impact corresponding to anesthetic actions, and it was classified into Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (thyroid), Category 2 (nervous system, testis) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (thyroid)
H373: May cause damage to organs through prolonged or repeated exposure (nervous system, testis) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to the descriptions that many thyroid disorders were observed in the occupational exposure example in IARC 53 (1991), that the effects on the nervous and thyroid system was observed within the guidance value of Category 2 in the oral study using the rats in EHC 78 (1988), ACGIH (7th, 2001), IARC 53 (1991), and IRIS (2006), and that the effect on the testes was observed in the oral study using the rats with the given dose of the guidance value range of Category 2 in ACGIH (7th, 2001), they were classified into Category 1 (thyroid) and Category 2 (nervous system, teste).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=13.2microg/L of fishes (Fathead minnows) (MOE Risk Assessment No.2, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 2.8% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow=1.73(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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