GHS Classification Result

Chemical Name：Trichloroethylene
CAS：79-01-6

Result：
ID: 161
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - There is no flash point (c.c.), according to NFPA (13th, 2002), while the gas combustion explosion DB indicates that the flash point is 32degC. Information on the flammability varies from reference to reference.
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing unsaturated bonds. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 6.1, UN#1710)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 410degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1710) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the testing data of rat LD50 (oral route) of 5,400-7,200mg/kg (ATSDR (1997), EU-RAR No.31 (2004)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the testing data of rabbit LD50 (dermal route) of 29,000mg/kg (NICNAS No.8 (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the LC50 value (4 hours) of 4,800ppm, calculated from the lower value of testing data of rat LC50 (4-hour inhalation of vapour) of 26mg/L (NICNAS No.8 (2000)) and 64mg/L (EU-RAR No.31 (2004)), was lower than 90% of the saturated vapour concentration (77,000ppm) under a saturated vapour pressure of 7.8kPa (20degC) (IPCS (2004)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of severe primary skin irritation in rabbit primary skin irritation tests (EU-RAR No.31, 2004).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in EU-RAR No.31 (2004) of human accidents: an accidental exposure to a droplet of undiluted solution caused eye irritation and corneal epithelial damage, both of which healed completely after a few days; the substance is considered "mildly irritating" to the eyes, though the amount of the droplet is unknown. The results of rabbit eye irritation tests, meanwhile, suggest mild to severe conjunctivitis and epithelial keratosis (after seven days of exposure), both of which healed after two weeks.
4 Respiratory sensitization Not classified - - - - Based on the description in EU-RAR No.31 (2004) "there is no report indicating respiratory sensitization in humans, while accidental inhalation exposure cases suggest that trichloroethane does not cause respiratory sensitization."
4 Skin sensitization Classification not possible - - - - Based on the description in EU-RAR No.31 (2004) - Although two cases are reported where patch tests on those who accidentally inhaled trichloroethane and developed cutaneous symptoms show positive, reports on human skin sensitization are sporadic and sensitization development is considered unique to idiosyncratic individuals; trichloroethane should not be considered to cause skin sensitization. No other information is available and data are insufficient.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.37 (2004), EU-RAR No.31 (2004), ATSDR (1997).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Group 2A by IARC, Category R by NTP (2005) and Category A5 by ACGIH.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.37 (2004): Behavioral changes are observed in offspring at dosing levels not toxic to parental animals (Taylor et al.)
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "loss of consciousness, headache, nausea, lacrimation, eye irritation" (CERI-NITE Hazard Assessment No.37 (2004)), and the evidence from animal studies including "anesthesia, eye/respiratory irritation, impaired coordination, depression of the central nervous system, respiratory depression; major toxic symptoms include depression of the central nervous system; no significant changes are observed in the lungs, liver and kidneys," "vacuolation of the Clara cells in the bronchial branches; patchy loss of the epithelium" (CERI-NITE Hazard Assessment No.37 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "narcotic influence, adverse effects on the central nervous system and anaclisis (as suggested by epidemiological studies)," "depression of the central nervous system (as suggested by many reports on the repeated-dose toxicity to humans)" "exhaustion, vertigo, dizziness, headache, amnesia, lack of concentration (common symptoms)" (CERI-NITE Hazard Assessment No.37 (2004)).
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in ICSC (J) (2002): "May cause aspiration and chemical pneumonia if swallowed (liquid)."

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=7.40mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=17(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 2.4%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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