GHS Classification Result

Chemical Name:Methane, trichlorofluoro-
CAS:75-69-4

Result:
ID: 162
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (ICSC(J), 2002; etc.).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC(J) (2002) ; etc.)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(J), 2002; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes metal under presence of moisture (solvents handbook (1994)), there is no data based on set test methods.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on general lethal doses of rat: 3725mg/kg (ACGIH 7th, 2001), it was set as the outside of Category.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Based on rat LC50 (4 hours) value: 26200ppm (equivalent of 146.9mg/L) (CERI Hazard Data, 1999, Industrial Hygiene Society advice, 1993), it was classified as out of Category. The vapor pressure of 26200ppm indicates steam with almost no mist, and it was classified by the ppm concentration standard.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - There is the descriptions that although applications on the skin of rats and rabbits indicated transient mild irritation, no damage was observed (CERI Hazard Data (1999), ACGIH (7th, 2001)). And it was judged not to match the diagnostic criteria of irritation and classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - There is description that although transient mild irritation was indicated by apply to rat and rabbit eyes, damage was not seen ( CERI Hazard Data (1999) and ACGIH (7th, 2001)), and description that although slight inflammation with a conjunctiva was acknowledged by apply to the eye of rabbit but change was not acknowledged in cornea and iris (DFGOT (vol.1 1991)). So it was judged that it did not correspond to a stimulative judgment standard, and was considered as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although EHC 113 (1990) describes that a patch test in humans found positive, there are no other cases reported and this case does not fit the skin sensitization criteria. We therefore classified this uncategorizable because of insufficient data.
5 Germ cell mutagenicity Classification not possible - - - - Although there are negative results from the unscheduled DNA synthesis test (CERI Hazard Data, 1999), which is an in vivo genotoxicity test using somatic cells, it was decided that the substance could not be classified because there are no other data from in vivo tests.
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There were the increase of embryonic/fetal deth and the increase of incidence of teratosis of children only in the dose causing general toxicity to parent animals in the inhalation exposure test during pregnancy using rat and rabbit (DFGOT (vol.1, 1991)). So it was considered as in the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (heart), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (heart)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There is the descriptiosns that the anesthetic actions, irritation to respiratory organs, and effect to the heart were observed in human exposure examples in CERI Hazard Data (1999), ACGIH (7th, 2001), EHC 113 (1990), industrial hygene academic society advice (1993), and DFGOT (vol.1, 1991). And that also in animal studies, the anesthetic actions, irritation to respiratory organs, and effect to the heart were observed. So they were classified into Category 1 (heart) and Category 2 (anesthetic action, respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In repetitive inhalation exposure or an oral administration examination using laboratory animals in CERI Hazard Data (1999), ACGIH (7th, 2001), industrial hygene academic society advice (1993), PATTY (4th, 1994), EHC 113 (1990), and DFGOT (vol.1, 1991), serious toxicities were not observed even at high doses exceeding the guidance value range of Category 2, and in the two to four-week exposure tests to human in CERI Hazard Data (1999), CERI hazard data, EHC 113 (1990), DFGOT (vol.1, 1991), PATTY (4th, 1994), and ACGIH (7th, 2001), serious toxicities were not observed. Based on above descriptions it was carried out the out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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