GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Benzene, 2-methyl-1,3,5-trinitro-
CAS：118-96-7
Result：
| ID: | 164 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Division 1.1 |
|
Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
UNRTDG Class: 1.1D |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified in explosives |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Calculated based on 795 to 3140 mg/kg (CERI Hazard Data (2001)), 795mg/kg (ACGIH (7th, 2001), DFGOT (1991), IARC 65 (1996), 1663.8 mg/kg (DFGOT (1991)), and 820mg/kg (DFGOT (1991)). Since the calculation values were lower than the lowest values of these data, it was set as Category 4 using 795mg/kg of the lowest value. LD50=795mg/kg. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on the descriptions that dermatitis was found in human exposure case (ACGIH (2001), DFGOT (1991), and IARC (1996)), and that it has irritation to the skin (CERI Hazard Data (2001) and industrial hygiene society advice (1993)), it was classified as Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
It was set as Category 2A from description that it had irritant to human eye in CERI Hazard Data(2001). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Classified as Category 1 because IARC (1996) describes that there is a report of allergic contact dermatitis in humans. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | The substance was regarded as outside the categories based on the records of negative results of the micronucleus tests using mammalian erythrocytes (CERI Hazard Data (2001), IARC (1996), IRIS (2005)). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | It is classified into a group 3 according to IARC (1996) and is classified into C according to EPA (1986). So it was set as the outside of Category. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is description which suggests the influence on the reproductive function in the occupational exposure study on male (PATTY (4th, 1994)) and there is a description about the result of the case-control study which indicates the decrease of amount of seminal fluid and sperm motility, and increases of abnormal spermatozoa (ATSDR (1995)), however, it is indicated that they are insufficient as an evidence of being the effect by exposure. On the other hand, there is description that testicular atrophy was observed with the dose occuring other toxic effects in repeated exposure to the rat (ACGIH (2001), DFGOT (1991), IARC (1996), and Industrial Hygene Academic Society Advice (1993)). Therefore, it was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood, liver), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (blood, liver) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Due to the descriptions that the toxicity is the effect on the hematopoietic system and liver damage in CERI Hazard Data (2001), that methemoglobinemia was observed in human exposure examples in ACGIH (2001), and that liver damage was observed in human exposure example in DFGOT (1991), it is considered that target organs are blood and liver. So it was classified into Category 1. Moreover, due to descriptions that it may be irritated to the human nose and the human throat in ACGIH (2001) and PATTY (4th, 1994), and that there is much onset of respiratory symptoms in IARC(1996). So it is considered that it has respiratory irritantation, therefore, it was classified into Category 3. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood, liver, eye, heart, peripheral nervous system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood, liver, eye, heart, peripheral nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Due to the descriptions that in CERI Hazard Data (2001) the a chronic effects were hepatic dysfunction, anemia, and cataract, that in the humans exposure examples in ACGIH (2001), DFGOT (1991), IARC (1996), PATTY (1994), and industrial hygene academic society advice (1993), anemic, hepatic dysfunction, and cataract were observed, that in the occupational exposure examples in DFGOT (1991) and PATTY (1994), arrhythmia and peripheral neuritis were observed, it is considered that the target organs were blood, liver, eyes, the heart, and the peripheral nervous system, and they were classified into Category 1. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96-hour EC50=0.62mg/L of algae (Selenastrum) (CERI Hazard Data, 2002). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.6(PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |