GHS Classification Result

Chemical Name：Nickel
CAS：7440-02-0

Result：
ID: 169
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible, because of the unidentified configuration and the absence of data. The substance, in the form of powder or vapor, is flammable (ICSC (2004)) and, as far as metals are concerned, the finer the particles, the more dangerous they are, according to Sax (11th, 2004). Metal powder (combustibles) (except those identifiable by name) is classified into Divisions 4.1, Packing Group II and III (UN Recommendations on the Transport of Dangerous Goods, UN#3089).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - The substance is stable in the air at ordinary temperatures (Merck (13th, 2001)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is stable in the air and does not react with water (Merck (13th, 2001))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Because the rat LD50 (oral route) values of >=9,000mg/kg (ECETOC TR33 (1989)) and >=5,000mg/kg (ECETOC TR33 (1989)) exceed 5,000mg/kg.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified into "Respiratory Sensitizing Substance: Group 2" according to the Recommendation on Occupational Exposure Limits for Chemical Substances (Japan Society for Occupational Health (2005)) and "Respiratory Sensitizing Substance" by the Japanese Society of Occupational Allergy and DFG.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified into "Skin Sensitizing Substance: Group 1" according to the Recommendation on Occupational Exposure Limits for Chemical Substances (Japan Society for Occupational Health (2005)) and Skin Sensitizing Substance by the Japanese Society of Occupational Allergy and DFG.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests)
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R (as metal nickel) by NTP (2005), Category 2B (as metal nickel) by IARC (1990).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, kidney) Danger H370: Causes damage to organs (respiratory system, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "alveolar wall damage, alveolar edema and significant renal tubular necrosis" (ATSDR (2005)). The acute toxicity of nickel compounds manifests in humans as "nausea, diarrhea, dizziness, headache" (ECETOC TR33 (1989)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The respiratory organs are considered to be the target organs since there are reports on adverse effects such as "pleurisy, pneumonia, congestion, and edema"(CaPSAR (1994)) and then "focal accumulation of alveolar macrophages and interstitial"(ATSDR (2005)). These effects were observed at dosing levels within the guidance values for Category 1 in the chronic studies. Therefore, the substance was classified as Category 1 (respiratory organs). The chronic toxicity of nickel compounds in humans is mentioned as follows: "Chronic exposure to nickel and its compounds may produce respiratory irritation and degeneration in humans even at doses close to occupational exposure limits. Prolonged exposure to high concentrations is likely to result in the fibroid lung"(ECETOC TR33 (1989)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data
11 Hazardous to the aquatic environment （Long-term） Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although L(E) C50 <=100 mg/L data existed, since it was metal and the behavior in the water was unknown, it classified into Category 4.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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