GHS Classification Result

Chemical Name：Aniline, 4-nitro-
CAS：100-01-6

Result：
ID: 171
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 6.1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG Class: 6.1
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 6.1
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 510degC (Hommel, 1991, Card No.293)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG Class: 6.1
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 value: 3249mg/kg (Japan Society for Occupational Health advice, 1995), 3250mg/kg (CERI Hazard Data, 2002), and 750mg/kg (CERI Hazard Data, 2002). Since the calculated values was 1049mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - There was description of rat LD50 value:>2500mg/kg in IUCLID (2000). But there was no other data and it was not able to judge Category 5 or outside of Category, itcannot be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - In the application test on rabbit skin, irritation was not observed (CERI Hazard Data (2002)), therefore, it was classified as out of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - There is description that irritation was not admitted in the test applied to the eye of the rabbit (CERI Hazard Data (2002)). But there is description that an eye was slightly stimulated as human impact (ACGIH (7th, 2001)). It was not clear about the irritation presence to eyes, it could not be classified.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because CERI Hazard Data Category (2002) describes that a test using guinea pigs finds no sensitization.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories because there is a record of a negative result from the micronucleus test (subjected tissue unknown), which is an in vivo mutagenicity test in IUCLID (2000).
6 Carcinogenicity Not classified - - - - Not classified because of "A4" (ACGIH, 7th, 2001)
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the description that there is the increased of number of resorptions and fetal malformations only in the dose causing general toxicity to dam animals in peroral administration during pregnancy using rat (ACGIH (7th, 2001), PATTY (4th, 1994), CERI Hazard Data, and NTP TR418 (1993)). And it was considered as in the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (blood), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (blood)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Due to the descriptions that methaemoglobinaemia, giddiness and consciousness loss were observed in human accidental exposure in industrial hygene academic society advice (1995), ACGIH (7th, 2001), PATTY (4th, 1994), and CERI Hazard Data (2002), and that somnolence and convulsion were observed by oral administration to the guinea pigs in CERI Hazard Data (2002). So blood is the internal target organ, and it is judged that it has anesthetic actions. Ttherefore, it was classified into Category 3 (anesthesia action).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In industrial hygene academic society advice (1995), ACGIH (7th, 2001), CERI Hazard Data (2002), and NTP TR418 (1993), due to the description that the effect to the blood on methemoglobinemia etc. was observed within the dosage of the guidance value range of Category 1 in the two-week oral study using mouse or the four-week inhalation atmospheric exposure test using rats , it was classified into Category 1 (blood).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24-hour EC50=25mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=3.6 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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