GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,2-Ethanediol, dinitrate
CAS：628-96-6
Result：
| ID: | 172 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Division 1.1 |
|
Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
UNRTDG Class: 1.1D |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | UNRTDG Class: 1,1D |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified in explosives |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 1.1D |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on rat oral LD50 value = 616mg/kg (CERI Hazard Data, 2001), it was set as Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rat percutaneous LD50 value = 16000mg/kg (Japan Society for Occupational Health recommendation, 1986), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | There is description which suggests the possibility of skin irritations (HSFS, 1999). But there is no other information. Therefore, it cannot be classified because of insufficient data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Although there is description (PATTY, 1994) which indicates very slightly irritating to the eyes in human. But there is no information in others including concrete case reports, and data is insufficient, it cannot be classified. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, blood) |
|
Danger | H370: Causes damage to organs (cardiovascular system, blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the description that arrhythmia, hypotension, methaemoglobinaemia, and Heinz snug formation were observed in human exposures (in CERI Hazard Data (2001)), and that the blood-pressure decreased was observed in human exposure example (ACGIH (2001), PATTY (1994)). So it is considered that the target organs are cardiovascular systems and blood, therefore, it was classified into Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system), Category 2 (blood) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system) H373: May cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Due to the descriptions in ACGIH (2001), PATTY (1994), and industrial hygene academic society advice (1986) (CERI Hazard Data(2001) that attack like angina pectoris, hypotension, or arrhythmia were observed in humans exposure example, and that the mortality rate according to heart disease at exposure example is high (from ACGIH (2001) and PATTY (1994)), it is considered that target organ is cardiovascular system, and it was classified into Category 1. Furthermore, due to the description (CERI Hazard Data (2001)) that the Heinz body was observed by the six-month inhalation study of rats and guinea pigs by moderate exposures, it is considered that blood was also target organ and it was classified into Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |