GHS Classification Result

Chemical Name：p-Nitrochlorobenzene
CAS：100-00-5

Result：
ID: 174
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Containing nitro groups, with the oxygen budget calculated at -122. However, No data available on kick-off temperatures and decomposition energy. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 6.1, UN#1578)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1578)
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing nitro groups. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 6.1, UN#1578)
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1578)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 82-84degC (ICSC, 1999), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to carbon and hydrogen. Not classified, based on the classification by UN Recommendations on the Transport of Dangerous Goods (Division 6.1, UN#1578)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 433mg/kg calculated from the testing data of rat LD50 (oral route) of 530mg/kg (ACGIH (7th, 2001)), 294mg/kg (SIDS (2002)), 565mg/kg (SIDS (2002)), 664mg/kg (SIDS (2002)) and 694mg/kg (SIDS (2002)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 750mg/kg representing the lower of the two testing data, 750mg/kg (SIDS (2002)) and 1,722mg/kg (SIDS (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data available
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.57 (2005)): The substance causes mild irritation, if any, to the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on germ cell multi-generation mutagenicity tests and mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests) and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.57 (2004).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Classified into Category 3 by IARC (1996), and into Category A3 by ACGIH (2001); priority is given to the latest evaluation document according to the guidelines.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.57 (2004) and SIDS (2005): Continuous breeding studies in mice indicate a significant decrease in conception rates; rat teratogenicity tests indicate skeletal malformations (mainly curbed ribs) in offspring at dosing levels toxic to dams; repeated inhalation exposure in rats and mice results in spermatogenic disorder, shorter sexual cycles (rats) and longer sexual cycles (mice).
8 Specific target organ toxicity - Single exposure Category 1 (blood) Danger H370: Causes damage to organs (blood) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.57 (2004): hemolytic anemia due to methemoglobin formation, and cyanosis are observed in human cases.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "cyanosis, an increase in methemoglobin concentrations, a decrease in red blood cell count, a decrease in hematocrit/hemoglobin values, an increase in the absolute/relative weight of the spleen, splenic hypertrophy, splenic extramedullary hematopoiesis, hemosiderin deposition, bone marrow hyperplasia, a decrease in spermatid count and sperm concentrations, impaired sperm mobility, testis atrophy, seminiferous tubule atrophy" (CERI-NITE Hazard Assessment No.57 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=2.14mg/L of the crustacea (Penaeus Chinensis) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=20.9(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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