GHS Classification Result

Chemical Name：Oxirane, phenyl-
CAS：96-09-3

Result：
ID: 180
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not classified - - - - The ignition points is 435 degC. (Hommmel (1991) Card No.568)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on rat LD50 value: 2000 to 4290 mg/kg (CERI Hazard Data, 2002), the lowest value was adopted and it was set as Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LD50 value: 930mg/kg (CERI Hazard Data, 2002), rabbit LD50 value: 930-1184mg/kg (CERI Hazard Data, 2002), and 2830mg/kg (PATTY 4th, 1994), the lowest value was adopted and it was set as Category 3.
1 Acute toxicity （Inhalation: Gases） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - It may be Category 2 from the description, but LC50 value is not indicated. So it cannot be classified. The description of PATTY (4th, 1994) is that 3 of 6 rats died with 395ppm (saturated vapor concentration) of 4-hour exposure (equivalent of 1.94mg/L) and that 44 of 106 rats died with 300ppm (judging from the vapor pressure, it is considered to be steam with almost no mist) of 7-hour exposure (4-hour exposure equivalent of 1.95mg/L)
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 from description that irritation was found on human skin (CERI Hazard Data of (2002) and PATTY (4th, 1994)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From description that irritant was indicated to the eye of the human (CERI Hazard Data(2002)), and from description that although the eye was stimulated comparatively seriously, critical damage did not occur (PATTY (4th, 1994)), it was set to Category2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because CERI Hazard Data (2002) describes that skin sensitization is found in humans.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are negative results from the dominant lethal tests in mice (CERI Hazard Data, 2002, IARC 60, 1994) and from the chromosome aberration tests and the micronucleus tests (intraperitoneal administration or inhalation exposure) using bone-marrow cells from mice and hamsters, which are in vivo mutagenicity tests using somatic cells (CERI Hazard Data, 2002, IARC 60, 1994). But there are positive results from the chromosome aberration tests using oral administration of mouse bone-marrow cells (CERI Hazard Data, 2002, IARC 60, 1994) and there is no positive result in in vivo genotoxicity tests using germ cells. So the substance was classified as Category 2.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into group 2A according to IARC (IARC 60 (1994)) and into 2A according to Japan Society for Occupational Health (Japan Society for Occupational Health recommendation (2005)), into R according to NTP (NTP RoC (11th, 2005)), and is classified into the category 2 according to EU (EU-Annex I, 2005). So it was set as Category 1B.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there were the reduction of fertility by resorption preimplantation embryo, and the increase of resorption in the dose causing general toxicity such as the death of maternal animals in the rat and rabbit pregnancy inhalation exposure test (CERI Hazard Data (2002), IARC 60 (1994) and PATTY (4th, 1994)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the descriptions that central nervous systems may be affected by effect of short-term exposure in ICSC (J) (1994) and of SITTIG (4th, 2002), and that headaches, dizziness, etc. may be started by short-term exposure in HSFS (1999). So it was classified into Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since there is the description that it is impaired to human liver in HSFS (1999) and SITTIG (4th, 2002), it is judged that target organ was liver, and it were classified into Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=1.9mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 81% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=1.61 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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