Chemical Name:Di-n-butyl phthalate
CAS:84-74-2
ID: | 182 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 157degC (c.c.) (ICSC, 2002) |
7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 402degC (ICSC, 2002) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the LD50 value of 6,300 mg/kg representing the lowest testing data of rat LD50 (oral route) of 6,300mg/kg and 8,000mg/kg, (EU-RAR No.29 (2003)), and over 20,000mg/kg (EHC 189, 1997). However acute toxicity was observed from a human case where a 23-year old male worker accidentally swallowed about 10g of the substance and suffered acute toxicity (EU-RAR No.29, 2003). |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rabbit LD50 (dermal route) of over 20,000 mg/kg (EU-RAR No.29 (2003)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified | - | - | - | - | Based on the rat LD50 (mist) of over 15.68 mg/L (EU-RAR No.29 (2003)). |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in CERI-NITE Hazard Assessment No.11 (2004) and EU-RAR No.29 (2003): The substance is "slightly to moderately irritating." |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in CERI-NITE Hazard Assessment No.11 (2004) and EU-RAR No.29 (2003): The substance has irritation to eyes but recovery observed 48 or 72 hours later. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Phthalic acid di-n-butyl does not cause skin sensitization in experimental animals (EU-RAR No.29 (2003), EHC 189 (1997)); some human cases suggest positive results; classified into "Skin Sensitization Group 2" by the Japan Society for Occupational Health (2005), and into "Skin Sensitization: Positive" by the Japanese Society of Occupational Allergy. | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the absence of positive data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo, described in CERI-NITE Hazard Assessment No.11 (2004). |
6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category D by EPA (1993). |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in CERI-NITE Hazard Assessment No.11 (2004): Rat and mouse reproductive toxicity tests suggest a decrease in F0 reproductive potential, testis atrophy, a decrease in sperm production potential, abortion during the middle stages of pregnancy, a decrease in litter size; Rat and mouse teratogenicity tests suggest malformations in offspring (external/skeletal malformations), and developmental abnormalities in the testes and accessory reproductive gland of next-generation rats; General toxicity to parental animals is observed; No description is available for the effects on parental animals. | |
8 | Specific target organ toxicity - Single exposure | Category 1 (kidney, nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (kidney, nervous system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including "large amounts of red/white blood cells in urinary sediments" (CERI-NITE Hazard Assessment No.11 (2004)), and the evidence from animal studies including "constrained respiration, ataxia, local paralysis, convulsions, coma, fatal cases in some animals due to respiratory paralysis" (CERI-NITE Hazard Assessment No.11 (2004)), "obvious irritation to the upper respiratory tract mucous membrane" (EU-RAR No.29 (2004)). The effects on nervous system of experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system), Category 2 (testis, liver) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) H373: May cause damage to organs through prolonged or repeated exposure (testis, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "seminiferous tubule degeneration, interstitial edema" (CERI-NITE Hazard Assessment No.11 (2004)), "hepatic atrophy and zonal necrosis" (EHC 189 (1997)), "dose-dependent acanthosis of the nasal mucous membrane" (EU-RAR No.29 (2004)). The effects on the respiratory organs and on the testes and liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 1 and Category 2, respectively. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours LC50=0.46mg/L of the fish (American Catfish) (EU-RAR (2004) and others.). | |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since there was rapidly degrading (the decomposition by BOD: 69% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (BCF=176 (Existing Chemical Safety Inspections Data)), it was claasified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |