GHS Classification Result

Chemical Name：Benzene, (trichloromethyl)-
CAS：98-07-7

Result：
ID: 191
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 211degC (ICSC(J) (1995))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 8
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although classified into the class 8 according to UNRTDG, there is no data used as the basis of metal corrosiveness.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 value: 736mg/kg (CERI Hazard Data (2002)), ACGIH (7th, 2001), DFGOT vol.6 (1994)), 1249mg/kg (SIDS (2004)), 1590mg/kg (SIDS (2004)), and 702mg/kg (SIDS (2004)). Since the calculated values was 718.3mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on rabbit LD50 value: 4000mg/kg (CERI Hazard Data (2002), SIDS (2004), DFGOT vol.6 (1994)), and rat LD50 value: >5000mg/kg (SIDS (2004)), the lower value was adopted and it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Lowar value was adaptted based on the rat LC50 with 4-hour exposure: 0.53mg/L (SIDS (2004)) and rat LC50 with 1 hour exposure: 8.39mg/L (4-hour equivalent is 4.2mg/L) (SIDS (2004), DFGOT vol.6 (1994)). 0.53mg/L was indicated steam with almost no mist from the vapor pressure. So it was classified according to the ppm concentration standard. It was classified as Category 1 based on the equivalent value (conversion coefficient: 1ppm =7.99mg/m3) was 66ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 from descriptions that irritation was observed in the application test on rabbit skin (CERI Hazard Data (2002) and SIDS (2004)) and from the report of human skin irritation (IARC 29 (1982) and CERI Hazard Data (2002)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From Descriptions that severe irritation was acknowledged by apply to the eye of the rabbit on CERI Hazard Data (2002) and SIDS (2004), and that change acknowledged by apply to the eye of the rabbit was recovered within 14 days on SIDS (2004), and that IARC 29 (1982) and CERI Hazard Data(2002) had eye or mucosal irritation reports in humans. So it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2. Because there are positive results from the chromosome aberration tests using rat bone-marrow cells, which are in vivo mutagenicity tests using somatic cells (CERI Hazard Data (2002), SIDS (2004), DFGOT vol.6 (1994)), and there is no positive result from in vivo genotoxicity tests using germ cells.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into 1 in Japan Society for Occupational Health (2005) and is classified into B-2 according to EPA (IRIS (Access on Oct 2005)). But it is classified into A2 according to IARC 29 (1982), and into 2A according to ACGIH (7th, 2001), and into R according to NTP (NTP RoC (11th, 2005)), and classified into category 2 according to EU (EU ANNEX-I (Access on Oct 2005)). So it was set as Category 1B.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is the description that there was skeletal malformation of embryo in the dose no general toxicity to maternal animals in the teratogenicity test of rat oral administration during organogenesis stage (SIDS (2004) and CERI Hazard Data (2002)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the description that excitability of the central nervous system was observed by inhalation exposure at low concentration in the range of guidance value of Category 1in rat and mouse in CERI Hazard Data (2002), ACGIH (7th, 2001), IARC 29 (1982) and DFGOT vol.6 (1994), it was judged that it has anesthetic actions. Moreover, due to the descriptions that the airway mucosa irritation was observed by inhalation exposure in rat and mouse in CERI Hazard Data (2002), ACGIH (7th, 2001), IARC 29 (1982), and DFGOT vol.6 (1994), and that it has the respiratory irritantation and the mucosa irritation in human in IARC 29 (1982) and CERI Hazard Data (2002), it is judged it has respiratory irritation, it was classified into Category 3 (anesthesia action, respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (inhalation exposure: liver, kidney, thyroid, blood, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (inhalation exposure: liver, kidney, thyroid, blood, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to the descriptions that in CERI Hazard Data (2002), SIDS (2004), and DFGOT vol.6 (1994), by the oral feeding administration tests using the rats, histologic changes was observed in the liver, the kidney and the thyroid gland, and that in CERI Hazard Data (2002), SIDS (2004), ACGIH (7th, 2001), IARC 29 (1982), or DFGOT vol.6 (1994), by the inhalation exposure test using the rat, leukopenia, mild anemia, renal dysfunction, bronchitis, pneumonia, or the fatty change of liver were observed, the liver, the kidney, thyroid, blood and respiratory systems were considered as target organs. Since all effects were observed by exposure within the guidance value of Category 1, these were classified into Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since description of "there is a risk of causing chemical pneumonitis by aspiration in swallowing fluid "( ICSC (J) (1995)) was judged to be described based on the evidence of humans etc., we classified into Category 2.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 24-hour EC50=50mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (it hydrolyzed and benzoic acid and hydrochloric acid are generated (CERI Hazard Data, 2002)), and supposed less bio-accumulative (log Kow=3.9 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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