GHS Classification Result

Chemical Name：Pentachloronitrobenzene
CAS：82-68-8

Result：
ID: 196
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Type G - - - - UNRTDG Non-hazardrous Substance
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not ignite spontaneously on coming into contact with air at normal temperatures
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not applicable - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The calculation formula was applied based on rat LD50 value: male 1710mg/kg, female 1650mg/kg (EHC 41 (1984)), 2140mg/kg (ACGIH (7th, 2001)), and > 5000mg/kg (JMPR, 1995). The acquired toxic value turned into a value lower than any value used for calculation. Therefore 1650mg/kg which is the lowest values used for calculation was adapted, it was set as category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit LD50: >5000mg/kg (JMPR, 1996), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There is a possibility of being in category 4, category 5, or outside of category from the data of rat LC50 (4-hour exposure): >1.7mg/L. But it cannot be classified since the category can not to be specified.
2 Skin corrosion/irritation Not classified - - - - Based on the descriptions that there was no irritation observed in the rabbit skin irritation test (JMPR and (1996), CERI Hazard Data (2002)) and that there was no primary irritation in the PCNB 75% hidrated agent skin application test on 50 persons (ACGIH and (7th 2001), JMPR (1969)), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - The very slight conjunctiva redness, edema were acknowledged transiently in rabbit eye irritation test. But diagnosis criteria of irritation in guidelines was not met. So it was considered as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because of the description that the skin sensitization test (modified Buehler test) using guinea pigs shows positive (JMPR, 1996), CERI Hazard Data, 2002), and because the skin patch test applying 75% PCNB wettable powder found positive in 13 out of 50 persons (ACGIH 7th, 2001, JMPR 1996).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because there are negative results from dominant lethal tests in mice, which are in vivo multi-generation mutagenicity tests using germ cells, and there are no results of mutagenicity tests in other in vivo test systems.
6 Carcinogenicity Not classified - - - - It classified into group 3 (IARC Suppl.7 (1987)) according to IARC and classified into A4 (ACGIH 7th, 2001) according to ACGIH. So it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there is the description of no effects on fertility property in the dose occuring general toxicity to parent animals in two generation rat reproduction study (CERI Hazard Data (2002)), and there is the description of no teratogenicity and no effect to embryo in the dose occuring the death of or general toxicity to maternal animals in rat mouse and rabbit fetal period of organogenesis administration test (ACGIH (7th, 2001), NTP TR 325 (1987), PATTY (4th, 1994), CERI Hazard Data (2002)), it is considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to the descriptions that in the study of feeding administration study in rat for two years, in a 400 ppm group (about 20mg/kg/day), centrilobular hepatocyte enlargement, single cell necrosis of hepatocyte, and adipose degeneration were observed and that in feeding administration study in dog for two years, mild atrophy of hepatocytes, periportal enlargement, leucocyte infiltration, and reversible cholestatic hepatitis were affected within the guidance value of Category 2 (CERI hazard data (2002)), it was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.01microg/L of Crustacea (Mysid shrimp) (MOE Risk Assessment No.1, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.64 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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