GHS Classification Result

Chemical Name:PCB 1254; polychlorobiphenyl; Chlorodiphenyl (42% chlorine)
CAS:1336-36-3,53469-21-9,11097-69-1

Result:
ID: 199
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC, Non-combustible (ICSC(J), 1999).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not combustible (ICSC (J) (1999)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1999))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 9

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 value of Aroclor 1254: 1010mg/kg (CICAD 55, 2003, ATSDR, 2000, PATTY 4th, 1994, EHC 140, 1992), 4000mg/kg (IARC 18, 1978, EHC 140, 1992), 1300mg/kg (IARC 18, 1978, EHC 140, 1992), 1400mg/kg (EHC 140, 1992), and 2000mg/kg (IARC 18, 1978, EHC 140, 1992). The calculated values became 1057mg/kg, and it was set as Category 4. Classified based on the toxic value of Aroclor 1254, because the toxic value of Aroclor 1254 was lower than Aroclor 1242. (About Aroclor 1242, it is in Category 5 based in rat LD50 values: 4250mg/kg (CICAD 55, 2003, ATSDR, 2000, EHC 140, 1992) and 8700mg/kg (IARC 18, 1978))
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3 based on rabbit percutaneous LD50 (MLD): 800mg/kg (EHC 140, 1992, ATSDR, 2000, IARC 18, 1978).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Since data is insufficient, it cannot be classified. Skin pathological changes, such as chloracne, were caused in the human occupational exposure (exposure to vapor). But there was no data about the stimulativeness at the time of the direct skin contact.
3 Serious eye damage/eye irritation Classification not possible - - - - There is description that eye irritation is acknowledged in human occupation evidence of exposure (exposure to vapor) (ATSDR (2000) and EHC 140 (1992)). But there is no animal examination data or human case report which attached PCB to eye surface directly. So it cannot be classified due to insufficient data.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because of the negative results from the dominant lethal tests in rats (ATSDR, 2003, IARC 18, 1978, EHC 140, 1992), from chromosome aberration tests in mammalian spermatogenic cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992), and from the chromosome aberration tests and micronucleus tests using mammalian bone-marrow cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992, NTP DB, Access on Oct 2005).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is classified into A3 according to ACGIH (7th, 2001) and is classified into B2 according to EPA (IRIS, Access on Oct 2005). But it is classified into 2A according to IARC (Access on Oct 2005) and into 2A according to Japan Society for Occupational Health (2005), and classified into R according to NTP (11th, 2005). So it was set as Category 1B.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is the description that there were the female reproductive toxicity such as menstrual irregularity, the decrease of reproductive potential of male, and fetal growth abnormality in the human exposure (CICAD 55 (2003), PATTY (4th, 1994), IARC 18 (1978), and ATSDR (2000)), it is classified into Category 1A.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the description that respiratory irritant is observed in human in ACGIH (7th, 2001), ATSDR (2000), and EHC 140 (1992), it is judged that it has respiratory irritant and it was classified into Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, skin, immune system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, skin, immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Due to the descriptions that in human exposure example, hepatic dysfunction (ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), skin condition, such as chloracne (CICAD 55, 2003, ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), and immune dysfunction (CICAD 55, 2003, EHC 140, 1992, ATSDR, 2000) were observed, it is considered that target organs were liver, the skin, and an immunity system and they all were classified into Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.008mg/L of fishes (Fathead minnows) (EHC140, 1993).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, stable in environmental, not rapidly degrading and bioaccumulative (BCF=270000 (EHC140, 1993)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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