GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Manganese dioxide
CAS：1313-13-9
Result：
| ID: | 201 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-flammable (ICSC, 2003) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (ICSC, 2003) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible (ICSC, 2003) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (insoluble, ICSC (2003)) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though being inorganic compounds containing oxygen which "intensifies combustion of other materials" according to ICSC (2003). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Not organic compounds |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the LD50 (oral route) value of 11,710mg/kg (CERI Hazard Data 2001-60 (2002). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | IUCLID (2000) reports epidemiological evidence of human exposure: "slightly irritating." However, classification is not possible since details are not available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | IUCLID (2000) reports epidemiological evidence of human exposure: "irritating." However, classification is not possible since details are not available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | CICAD 12 (1999) reports human epidemiological evidence suggesting skin sensitization. However, CICAD does not make conclusions about the presence of sensitization. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on expert judgment in the absence of existing classification. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) |
|
Danger | H370: Causes damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
"Acute exposure to manganese dust (in particular, MnO2 and M3nO4) induces pulmonary inflammation which progresses to pulmonary impairment with time. Pulmonary effects increase the infectiousness of bronchitis etc., resulting in manganese pneumonia" (CICAD 12 (1999)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, nervous system, cardiovascular system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, nervous system, cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "increased incidence of cases diagnosed as pneumonia," "the patient exhibited facial masking, reduced blinking reflex, micrographia, loss of associated arm movements, tremor of the right hand and some cogwheel rigidity of the right extremities," "psychopathological/neurological collapse" (EHC 17 (1981)), "impaired eye-hand coordination/visual reaction" (CICAD 12 (1999), "a greater incidence of low diastolic blood pressure," "impaired visual reaction time, hand-eye coordination, and hand steadiness" (ATSDR (2000)), and the evidence from animal studies including "sudden movement and torpor, nervousness, severe tremor, flexion-extension movements of upper limbs, yawning, and cyanosis; atrophy of the cerebellar cortex," "peribronchial and perivascular sclerosis and inflammatory changes" (EHC 17 (1981). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |