GHS Classification Result

Chemical Name：2-Propenenitrile, 2-methyl-
CAS：126-98-7

Result：
ID: 205
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point <23 degC, boiling point (initial boiling point)> 35 degC [special note] Although it will be classified as Category 1 according to the fact that it is classified into PGI in UNRTDG, it is clearly classified as Category 2 from the initial boiling point (boiling point substitute). Therefore, regarding the appropriateness of above classification, expert's judgement is required.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Classified in UNRTDG Class: 3, Subsidiary risks Class: 6.1
9 Pyrophoric liquids Not classified - - - - UNRTDG Class: 3 Subsidiary risks Class: 6.1
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3, Subsidiary risks Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Statistical calculations was applied based on rat LD50 values: 64, 240, 120, 25, 50, and 200 mg/kg (the Health, Labor and Welfare Ministry reports (2005), SIDS (2002), ACGIH (7th.2001)). Calculated values: It was set as Category 3 based on 58.3mg/kg.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Statistical calculations was applied based on rabbit LD50: 250, 280 and 256 mg/kg (SIDS (2002), ACGIH (7th.2001)). It was set as Category 3 based on calculation value: 250 mg/kg.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Statistical calculations was applied based on LC50 on rats: 0.899, 0.899, 1.92, and 1.36mg/L (SIDS 2002). It was classified as Category 2 based on calculated value of 0.899mg/L (equivalent to 328 ppm).
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the descriptions that there was mild skin irritation in Draize test on rabbits (SIDS, 2002) and it may cause dermatitis by repetitive or long-term skin contacts on humans, (MOE Risk Assessment the 3rd volume, 2004), it was judged to have mild irritativeness and was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Mild irritation was indicated to eye of rabbit. But it recovered within 1 hour (ACGIH 7th.2001). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although no skin sensitization is assumed to be found in guinea pigs (PATTY 4th.1994), this is uncategorizable because there is no data that clearly negate skin sensitization.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories based on the fact that it was negative in vivo micronucleus tests using both rat and mouse bone-marrow cells and mouse peripheral erythrocytes (SIDS 2002, NTP DB 2005, NTP TR 497, 2001).
6 Carcinogenicity Classification not possible - - - - Carcinogenicity is not observed in a study using rats and mice in which repetitive oral administration was performed for two years (NTP TR 497, 2001, MOE Risk Assessment SIDS, 2002, the 3rd volume, 2004). But data is insufficient, it cannot be classified.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the significant low sperm count of F1-generation male in two generation reproduction study, or the delay of estrous cycle of male after the last administration for 13 weeks (all are done by oral administration to rat, SIDS 2002, NTP DB 2005, MOE Risk Assessment the third volume 2004, NTP TR 497 2001), and the decrease of the male rate of offspring per litter in teratogenicity test (rabbit oral administration. SIDS 2002, CERI Hazard Data, 2001), the decrease of weight of fetus (rat inhalation exposure. SIDS 2002, CERI Hazard Data 2001, and NTP TR 497 2001) was observed, it is classified into the Category 1B.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		When it administers orally to rat in the range of guidance value of Category 1 (less than 300mg/kg), the symptom of central nervous systems, such ataxia, tremor, clonic convulsion, and hygrostomia, were observed (NTP TR 497 2001, the Ministry of Health, Labour and Welfare report 2005, SIDS 2002, ACGIH 7th. 2001), the same symptom was also observed in the aerial density about 1-2mg/L by inhalation to rat. So it was classfied into Category 1 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, central nervous system, sensory organ) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, central nervous system, sensory organ) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to repeated oral administrations to rats, some conditions, such as anemia, clonic convulsion, tremors, salivation, and ataxia, and histologic changes of the olfactory epithelium were observed in dosage within Category 1 (MHLW reports 2005, SIDS 2002, the 3rd volume of MOE Risk Assessment 2004, NTP DB 2005 and NTP TR 497 2001), the target organs were judged to be blood, the central nervous system, and the sense organ. When it makes dogs inhale, the symptoms of these central nervous systems was observed, and a histologic changes of brain was also observed (SIDS 2002 and ACGIH 7th.2001 and IRIS 2005, MOE Risk Assessment the 3rd volume 2004).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72-hour ErC50=25mg/L of algae (Selenastrum) (MOE eco-toxicity tests of chemicals, 1999).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 83% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.68 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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