GHS Classification Result

Chemical Name:Methyl-1,3-phenylene diisocyanate; m-Tolylene diisocyanate
CAS:26471-62-5

Result:
ID: 208
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flashing point of 1-methyl-2,4-phenylene-diisocyanate and 1-methyl-2,6-phenylene-diisocyanate is 127degC (ICSC (2004))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 620degC (ICSC, 2004) for both 1-methyl-2,4-phenylene-diisocyanate and 1-methyl-2,6-phenylene-diisocyanate
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2078)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 3,332mg/kg calculated from the testing data of rat LD50 (oral route) of 7,500mg/kg (CERI Hazard Data 97-20, 1998), 5,800mg/kg (NTP TR251, 1986) and 3,060mg/kg (EHC 75, 1987).
1 Acute toxicity (Dermal) Not classified - - - - Based on the LD50 value of 10,000mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 10,210mg/kg (CERI Hazard Data 97-20, 1998), 19,360 mg/kg (CERI Hazard Data 97-20, 1998) and 10,000mg/kg (EHC 75, 1987).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LC50 value (4 hours) of 26ppm, calculated from the testing data of rat LC50 (4 hour inhalation of dust/mist) of 0.099mg/L (CERI Hazard Data 97-20, 1998), 0.355mg/L (CERI Hazard Data 97-20, 1998), 0.34mg/L (EHC 75, 1987) and 0.355mg/L (EHC 75, 1987), was lower than 90% of the saturated vapor concentration (660 ppm) under a saturated vapour pressure of 67 Pa (25degC) (CERI Hazard Data 97-20, 1998), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the following descriptions in DFGOT Vol. 20 (2005) suggesting its irreversible effects, although the substance should be placed in Category 1A from the viewpoint of safety: "on the surface of the skin as well as necrosis and the formation of granulomas (rabbit 24-hour skin irritation tests)" and "undiluted TDI 80/20 was evaluated as caustic. The skin was visibly healing, but the changes were not completely reversible within the follow-up period of 8 and 28days (1- or 4-hour skin irritation tests)".
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the evidence of "irritation and mild damage to the corneal epithelium" in rabbit eye irritation tests (CERI Hazard Data 97-20, 1998), the evidence of "immediate reaction suggestive of pain, lachrymation, swelling of the eyelids, a conjunctival reaction and mild damage to the cornea" (EHC 75, 1987) and the evidence of human health effects found in CERI Hazard Data 97-20 (1998), NTP TR 251 (1986), EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004), suggesting irritation with unknown recovery time, although the substance should be placed in Category 2A from the viewpoint of safety.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Based on the evidence on human health effects from CERI Hazard Data 97-20 (1998), EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004) and the fact that the substance is classified as "respiratory sensitizing chemicals" according to the Japanese Society of Occupational Allergy and "Respiratory Tract Group 1" according to Recommendations by the Japan Society of Occupational Health (2005).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on positive results in animal skin sensitization tests reported by CERI Hazard Data 97-20 (1998), EHC 75 (1987) and DFGOT Vol. 20 (2005), the evidence of human health effects from EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004) and the fact that the substance is classified as "Skin Group 2" according to Recommendations by the Japan Society of Occupational Health (2005) and "SEN" according to ACGIH-TLV (2005).
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on heritable mutagenicity tests, germ cell mutagenicity tests in vivo, somatic cell genotoxicity tests in vivo and germ cell genotoxicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category A4 by ACGIH (2001), Group 2B by IARC 71 (1999) and Category 2B according to Recommendations by the Japan Society of Occupational Health (2004), and priority was given to the IARC classification, following the guidelines.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available. Moreover, although nasal inflammation and relevant changes in the pharynx/trachea and weight loss were observed in the progeny at dosing levels not toxic to the parents (IRIS, 1995), the effects were not significant compared with those on the parents.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, central nervous system) Danger H370: Causes damage to organs (respiratory system, central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "eye/respiratory/skin irritation, severe dry cough, sputum, strangalesthesia, dyspnea, nausea, vomiting, bronchitis associated with severe bronchospasm, pulmonary edema, pneumonia, long-lasting effects on the central nervous system including headache, amnesia, loss of concentration, distraction, personality changes, easy stimulability and depression" (CERI Hazard Data 97-20, 1998), "elation, ataxia, intermittent spasm in extremities, dizziness, loss of consciousness, headache, loss of concentration, memory disorder, confusion, irritability, depression (EHC 75, 1987).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (liver) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (liver)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "throat irritation, dyspnea" (EHC 75, 1987) and the evidence from animal studies including "nasal inflammation, interstitial pneumonia, catarrhal bronchitis, tracheitis, bronchitis and pneumonia associating an increase of fibrous tissues in the bronchiolar wall" (CERI Hazard Data 97-20, 1998) and "pathologic changes in the lung, trachea and liver attributed to test substance administration, bronchial pneumonia, regeneration/deciliation of the bronchial epithelium, fatty liver" (Report by the Ministry of Health, Labour and Welfare, 2001). The effects on the respiratory organs and on the liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 1and Category 2, respectively.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.153mg/L(the fish (Red sea bream)) of toluenediamine(hydrolysis product of this product) (CERI/NITE Hazard Assessment Report (preliminary version) (2006))
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.74(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI Hazard Data, 1997)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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