GHS Classification Result

Chemical Name：Butane, 1,2-epoxy-
CAS：106-88-7

Result：
ID: 224
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 2 because of its flash point: -12 to -22degC and initial boiling point: 63 to 63.3degC (ICSC, 2004)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Not classified based on UNRTDG Class: 3, though containing chemical groups associated with self-reactive properties present
9 Pyrophoric liquids Not classified - - - - Flash point: 439degC (ICSC, 1997; NFPA (13th, 2002); HSDB , 2003)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on LD50= 659.3mg/kg obtained from the calculation of rat four examinations (SIDS (2001), DFGOT vol.5 (1990)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on LD50= 1744mg/kg obtained from the calculation of rabbit three data (SIDS (2001), DFGOT vol.5 (1990), PATTY (5th, 2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The saturated vapor pressure concentration of this product is 171000ppm (58.0mg/L), and it is regarded that each inhalation test was done with vapor. There are two rat data with rat LC50 >18600ppm (SIDS (2001)) and rat LC50 >2000ppm (PATTY(5th, 2001) vol.6), but these data are greatly different from each other. Since the priority is equivalent, it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are statements that it has skin irritativeness on humans and produces redness (SIDS (2001), ICSC (J) (2000)). Although there are statements that skin irritation on rabbits were not observed under unsealed condition (SIDS (2001), DFGOT vol.5 (1990)), necrosis on all skin layer was observed on two out of four rabbits with 1 hour exposure under sealed condition. This is considered to be the necrosis which penetrates into dermis. Moreover, there is also a statement that there is corrosivityity under such conditions (SIDS (2001)). Although the effects on skin vary greatly with test conditions, from a viewpoint of safety, it was classified as Category 1A-1C based on the test data which observed critical disorders on animals(SIDS (2001)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on data (SIDS (2001)) that there is skin corrosivity with a rabbit, it was set as Category 1 according to the technological direction.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category based on the description of two maximisation tests and one guinea pig test, which does not describe the testing method, found no skin sensitization (SIDS (2001) and PATTY (5th, 2001).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories by the technical guidelines. Based on the report that the dominant lethal test in rats, the in vivo chromosome aberration test using rat bone-marrow cells and the in vivo genotoxicity test in rats were all negative (SIDS (2001)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on being classified into 2B according to IARC, and into 2B according to an industrial hygiene society, and classified into 3 according to EU. So it was set as Category 2 according to the technical guidelines.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is a descripton that child abortion and declining tendency in the number of litter size were observed with the motal dose in parent animals (SIDS (2001)) and although there is no description about the toxicity signs in parental animals, there is a description that decreased number of child and increased fetal absorption were observed in 2 of 24 cases (SIDS (2001)), it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there are the descriptions of respiratory irritantation in human (PATTY (5th, 2001)) and membrane irritatio and breathing difficulties in animals (SIDS (2001), DFGOT vol.5 (1990)). Based on this results that it has respiratory irritantation, it was classified into Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, respiratory system, kidney, olfactory organ) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system, kidney, olfactory organ) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There are statements of neurological symptoms such as a straub tail and movement instability (SIDS (2001)), hemorrhagic of pulmonaries (SIDS (2001), IRIS (2005), DFGOT vol.5 (1999)), nephropathy (SIDS (2001), and a renal tubular necrosis (SIDS (2001)) in studies using rats and mouse. Moreover, the findings of the inflammation or the necrosis of nasal tissues (membrane) are indicated in almost all data (SIDS (2001), IRIS (2005), DFGOT vol.5 (1999)). Based on the findings that every such development dose of toxicity was the amount of exposure in the range of Category 2 guidance value in repetitive exposure, it was classified in Category 2 (a nervous system, the respiratory system, the kidney, olfactus organ).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=69.8mg/L of Crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 109% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=0.86 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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