Chemical Name:7-oxa-3-oxiranylbicyclo[4.1.0]heptane
CAS:106-87-6
ID: | 225 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified | - | - | - | - | Flash point: >93degC |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | No data available |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 393degC (ICSC (J), 1998) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :2830mg/kg (ACGIH 7th, 2001; DFGOT vol.1, 1992) and 2130mg/kg (NTP TR 362, 1989) |
1 | Acute toxicity (Dermal) | Category 3 | Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 based on rabbit LD50 value: 680mg/kg (ACGIH 7th, 2001, DFGOT vol.1, 1992, NTP TR 362, 1989). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 | Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on rat LC50 (4 hours) value: 800ppm (equivalent of 4.58mg/L) (DFGOT vol.1, 1992, PATTY 4th, 1994, NTP TR 362, 1989), vapor pressure of 800ppm indicates steam with almost no mist. And it was classified as Category 3 by the ppm concentration standard. | |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Based on the descriptions that edema and erythema were observed in the rabbit skin application test (ACGIH (7th, 2001) and NTP TR 362 (1989)) and that severe irritation was observed in Draize test on rabbits (PATTY (4th, 1994)), it was classified as Category 2 . | |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
It was set as Category 2A from description that severe irritation (highly irritating) was accepted in the test applied to the eye of the rabbit of ACGIH (7th, 2001). | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
4 | Skin sensitization | Classification not possible | - | - | - | - | ACGIH (7th, 2001), PATTY (4th, 1994), and IARC 60 (1994) describe one case of allergic contact dermatitis, which do not fit the criteria since they all describe the same case. We therefore classified this as uncategorizable because of insufficient data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There are no results from in vivo tests. Although there are positive results from the chromosome aberration test and the gene mutation test using mammalian cultured cells and the bacterial reverse mutation test (ACGIH 7th, 2001, DFGOT vol.1, 1992, IARC 60, 1994, NTP DB, 2005), after reviewing the original document, the in vitro mutagenicity test were strongly positive for several parameters. So it was decided that the substance could not be classified. |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It is classified into 2B according to IARC (IARC 60, 1994), and into 2B according to Japan Society for Occupational Health (Japan Society for Occupational Health magazine 47, 2005), and into A3 according to ACGIH (ACGIH 7th, 2001) , and is classified into R according to NTP (NTP Roc 11th, 2005). So it was set as Category 2. | |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there is the effect to ovaria and testis in 13-week oral administration test using rat and mouse, and the effect to ovaria in 13-week dermal administration test using mouse (NTP TR 362 (1989)), it is classified into the Category 2 | |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects, Respiratory tract irritation) | Warning |
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the description that respiratory irritant was observed in the inhalation exposure test using the rat in ACGIH (7th, 2001), it was classified into Category 3 (respiratory irritant). Moreover, due to the description that loss of activity and staggering gaits were observed in the oral single dose and dermal administration studies using rat and mouse in NTP TR 362 (1989). So it is judged that it has anesthetic actions, therefore, it was classified in to Category 3 (anesthetic action). | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (immune system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (immune system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
From description in NTP TR 362 (1989), ACGIH (7th, 2001) and PATTY (4th, 1994) that immunosuppressive was seen with the given dose of the guidance value range of Category 2 in immune functional test by dermal exposure during 14 days using the mouse, it was classified in Category 2 (immune systems). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | No data available |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | No data available. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
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