GHS Classification Result

Chemical Name:Benzene, diethenyl-
CAS:1321-74-0

Result:
ID: 231
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: 76degC(o.c.)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Although the grouping relevant to autoreactive was included in the molecule but includes a polymerization inhibitors are does not polymerize in room temperatures. So it was taken as Type G.
9 Pyrophoric liquids Not classified - - - - The ignition points is 500 degC and does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available on corrosion to metals

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Rat ENDPOINT: LD50 VALUE: 2155 mg/kg, 4100 mg/kg REFERENCE SOURCE: ACGIH (2001)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Death is not observed with 645ppm in 7 hour toxicity-by-inhalation test on rats. But there is no level of LC50, it cannot be classified.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the information that it causes mild irritation on humans (ACGIH (2001)) and that it caused erythema, scaling, dropsy, and moderate necrosis on rabbits (ACGIH (2001)), it was classified as Category 1.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Since the inflammation of the conjunctiva remained even if it left on the 8th by moderate pain by applying-eyewash medication of the rabbit (ACGIH (2001)), it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there are positive results from in vivo micronucleus tests (MIN), cytogenetic assays (CAs) and sister chromatid exchange tests (SCEs), these tests are not germ cell tests. So the substance was classified as Category 2
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is observed mammary gland hyperplasia and bad nesting and newborns are all died in 7/9 cases in the 1000mg/kg dosage group in the oral administration of female and male rat. There was the decrease of the number of corpus luteum and the number of implantation trace, and implantation rate, and there was the decrease of the total number of baby, of the number of new born of no lactation, of the birth rate and of the number of survival baby of 4 nursing day and of the survival rate, and there was the tendency to be low of delivery rate and the neonatal reproductive rate. However, there is no effect to parent animals and new born in the dose 1000mg/kg or less (Health, Labor and Welfare Ministry reports (2006)). Since this effect is checked as secondary toxicity of parent animals because the toxicity is not occured in the next generation in the dose that parent animals do not have toxicity, it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects, Respiratory tract irritation) Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the inhalation atmospheric exposure test (7-hour single times) in five rats, nasal secretions was occured at 2340ppm exposure. In 3312ppm, ataxia, tachypnoea, eye irritation, and rhinitis were developed during exposure, and the symtoms of decreased weight and lethargic developed for more than 14 days. In 4835ppm exposure, three of five animals dead within 24 hours, and after exposure bloody urine and decreased weight were observed in the survived individual (ACGIH (2001)). Thereby, it was classified into Category 3 (anesthetic action). Moreover, the respiratory tract irritation is reported as acute symptoms by the human occupation exposures (ACGIH (2001)). So it was classified into Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, thymus) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, thymus) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
By the rat inhalation exposure, in the range of the value of Category 2 ,"Reduction of thymus size" is seen, moreover, "centrilobular hepatocyte growth, nephrosis, and kidney tubulars dilatation" are seen in the range of the value of Category 2 by inhalation exposure of a mouse (ACGIH (2001)).
10 Aspiration hazard Classification not possible - - - - No data available on chemical pneumonia

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72-hour ErC50=1.8mg/L of algae (Selenastrum) (MOE eco-toxicity tests of chemicals, 1997).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=433(m-), 402(p-) (existing chemical safety inspections database)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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