GHS Classification Result

Chemical Name:thallium
CAS:7440-28-0

Result:
ID: 233
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although it is thought that an aggregated metal does not burn, metal powder burns easily. The object should be classified after defined test was carried out.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - There is no information that it ignites spontaneously in the reliable data collection of physicochemical nature.
11 Self-heating substances and mixtures Classification not possible - - - - In the case of powdered, the test data on self-heating cannot be found out, and cannot be classified.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - There is a statement of not dissolving into water and it is thought that severe reaction does not start.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - Since there is no LD50 data about metals thallium, it cannot be classified. If this metal touches with air, the surface will oxidize. There is data of 32mg/kg (EHC 39 (1984)) in LD50 of an oxide, and it is thought that Category 2 level is appropriate for powder.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is no acute inhalation-toxicity-test result about steam, and it cannot be classified. It is the metal of nonvolatility and it is thought that the inhalation test in steam cannot be done.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - There is no Draize test data on animals, and it cannot be classified. As for the compounds, intense influence on the skin at the time of the human addiction has been found.
3 Serious eye damage/eye irritation Classification not possible - - - - There is no eye dose response data, and it cannot classify.
4 Respiratory sensitization Classification not possible - - - - Uncategorizable because of no information related to sensitization.
4 Skin sensitization Classification not possible - - - - Uncategorizable because of no information related to sensitization.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as "Category 1B" because the dominant lethal test in rats using thallous carbonate was positive (EHC 39 (1984)). Metal thallium can be turned into thallous carbonate by oxygen and carbon dioxide in the air.
6 Carcinogenicity Classification not possible - - - - There is no information about metal thallium. EPA has been classified into D about the compound. Moreover, there is also information (EHC 39 (1984)) that a tumor-suppressing effects occurs. On the other hand, Lide (2004) has the statement which suggests carcinogenicity.
7 Reproductive toxicity Category 1A, Additional category: Effects on or via lactation Danger H360: May damage fertility or the unborn child
H362: May cause harm to breast-fed children
P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P263: Avoid contact during pregnancy/while nursing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
Since there is the example of human transplacental alopecia by the intake of thallium compound (ACGIH (2001)), it is classified into the "Category 1A." The effect to sperm, neonatal chondrodysplasia and infant alopecia via lactation are also reported in the animal experiments (ACGIH (2001), EHC 39 (1984)).
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, nervous system, skin appendage) Danger H370: Causes damage to organs (digestive system, nervous system, skin appendage) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the gastroenteritis, polyneuropathy, and acomia are major symptoms of thallium poisoning (EHC 39 (1984)), it was classified into "Category 1 (digestive systems, nervous systems, skin (appendage))".
9 Specific target organ toxicity - Repeated exposure Category 1 (circulatory system, brain, nervous system, skin appendage) Danger H372: Cause damage to organs through prolonged or repeated exposure (circulatory system, brain, nervous system, skin appendage) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Although circulatory systems,nervous systems and alopecia were taken based on the statement of ICSC (2002), since the effect to brain in the animal experiments was described, it was classified in "Category 1 (circulatory system, a brain and a nervous system, attached vessel)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 4, since it is metal and the behavior in the water is unknown, though L(E) C50 <=100 mg/L .


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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