GHS Classification Result

Chemical Name：Ethane, 1,1,2,2-tetrachloro-
CAS：79-34-5

Result：
ID: 234
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (Merck, 13th, 2001; Chapman, 2005; Hommel, 1991; Weiss, 2nd,1985; Incompatible Hazard Hand Book, 2nd, 1993).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - It is nonflammable (Merck (13th, 2001), Chapman (2005), Hommmel (1991), Weiss (2nd, 1985), incompatible hazards Hb (the 2nd edition, 1993)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - It is nonflammable (Merck (13th, 2001), Chapman (2005), Hommmel (1991), Weiss (2nd, 1985), mixed touch dangerous Hb (the 2nd edition, 1993)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Not classified - - - - NRTDG No. 1702, Class: 6.1, PGII(UN )

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Statisticals calculation was done using rat oral LD50=1000 mg/kg, 250 mg/kg, 330 mg/kg, and 319 mg/kg (ACGIH (2001), CICAD 3 (1998), ATSDR (1996)). But the result is lower than lowest values of the used value, lowest value 250 mg/kg was adopted. It was set as Category 3 based on rat oral LD50=250 mg/kg.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit percutaneous LD50 = 6300mg/kg (ACGIH (2001)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are two results with rat LC50 : 1000ppm (ACGIH (2001)) and 1253ppm (ATSDR(s) (1996)). And saturated vapor pressure concentration was calculated to be about 6000 ppm, both values are considered to steam. Therefore, it was classified as Category 3 based on the lower result of rat LC50 = 1000ppm (ACGIH (2001)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 based on change of the skin on rabbits, congestion, dropsy, serious blister formation, and being highly and moderately irritating (CICAD 3 (1998), ATSDR (1996), IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From Draize score (42.5/110) in the rabbit, there is a stimulus of the degree of middle class (IUCLID (2000)), and it was set as Category 2A based on what irritation is acknowledged for also by humans (ATSDR (1996)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance is negative in the dominant lethal test in rats (CICAD 3(1998)), but it is positive in the in vivo micronucleus test using mouse peripheral blood (NTP TOX-49 (2004)). Therefore, although there are negative data from multi-generation mutagenicity tests, and positive data from mutagenicity tests using somatic cells, but there is no data from in vivo genotoxicity data for germ cells. So the substance is classified as Category 2.
6 Carcinogenicity Not classified - - - - The category of IARC which is the newest evaluation document was a group 3, based on the guideline. So it was set as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - Although there is the effect to reproduction parameter (change of estrous cycle) under the condition of the big weight decrease in oral administration of rat and mouse, and there is a report about the decrease of the weight of embryo and about the increase of fetal resorption under the condition of maternal toxicity (decrease weight gain and increase mortality) (CICAD 3(1998), NTP TOX49 (2004)), these have low importance. There is the effect on testes (atrophy, histological alteration) in rat oral test (ACGIH (2001), CICAD3(1998)), and there is the decrease of weight of testis and epididymis in the rat and mouse oral test(NTP TOX49 (2004)). However, there is the indication to relasionship with reduced weight gain (NTP TOX49 (2004)), and in the long term (78 weeks) test of rat and mouse it is not observed effects to reproductive organs (CICAD 3 (1998)). The reproductive tissue effects is not occured in all the inhalation tests (ACGIH (2001),CICAD 3 (1998)). On the other hand, there is almost no data about the reproductive function and reproductive potential. Therefore, it was considered that it cannot be classified because of the shortage of data. In addition, as reference, a high doses administration (300 to 700 mg/kg, mouse LD50=250 mg/kg) into the abdominal cavity of a pregnancy mouse causes ferotoxity and teratogenicity (ACGIH (2001), IARC 20 (1979)). [special notes] "an increase in embryo resorption" under the conditions of maternal toxicity which mortality rates increases was not considered as important effect. Moreover, effect on the reproduction parameter (change of the estrous cycle) under conditions of a severe weight decrease was not considered as important effect. Because, in (NTP ,the former literature of these data), as the summary of the reproductive and developmental toxicity in the introduction of the latest oral test for 14 weeks (NTP TOX49 (2004)), these above datas are not cited but two kinds of data (No.13, 14) with no effect or the lower incident of teratogenicity and a part of ferotoxity are cited. And as the conclusion, it said "Data is insufficient and a summary will not come out." Moreover, by the conclusion of ACGHI (2001), it is "not almost all data affects a reproductive systems alternatively." and it is no data in which "use is possible"(IARC 71 (1999)).
8 Specific target organ toxicity - Single exposure Category 1 (liver), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (liver)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was classified into Category 1 (liver). Based on the influence on the liver in mouse by taking orally (ACGIH (2001)). Moreover, it was classified into Category 3 (anesthetic actions, respiratory irritant) based on the description of the anesthesia action in human and animal (ACGIH (2001), PATTY (5th, 2001)) and the mucosal irritation in human (ACGIH (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the effect on the nervous system in humans (ACGIH (2001), CICAD 3 (1998), and PATTY (5th, 2001)), the effect on a liver in an animal (a rat, a mouse, a rabbit and a dog), its dosage and the guidance value (ACGIH (2001), CICAD 3 (1998), NTP TOX-49 (2004)), it is classified in Category 1 (nervous systems,liver).
10 Aspiration hazard Classification not possible - - - - Although dynamic viscosity (0.98 mm2/s) is less than 14 mm2/s, there is no information on chemical pneumonia.We could not classify it because of insufficient data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=9.3mg/L of Crustacea (Daphnia magna), and others (SIDS, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified out of Category since NOEC=6.9 mg/L during 28 days (ECETOC TR 91, 2003) for the Crustacea (Daphnia magna),though acute toxicity was Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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