GHS Classification Result

Chemical Name：Biphenyl
CAS：92-52-4

Result：
ID: 239
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - There is information on flame ranges (Hommmel (1991) Card No. 241 and others), there is no data with a defined test method.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 540degC (ICSC (J), 1994)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rat LD50 values: 2400mg/kg (CERI Hazard Data, 1999 and MOE Risk Assessment the 1st volume, 2002), 3280mg/kg (MOE Risk Assessment the 1st volume, 2002, ACGIH 7th, 2001, and PATTY 4th, 1994), and 5040mg/kg (CERI Hazard Data, 1999). Since the calculated values was 2489mg/kg, it was set as Category 5.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on rabbit LD50 value: 2500mg/kg (CERI Hazard Data, 1999, MOE Risk Assessment the 1st volume, 2002), and >5010mg/kg (MOE Risk Assessment the 1st volume, 2002), the lower value was adopted and it was set to as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There in only a data that mouse LC50 (4 hours) value: >43ppm (corresponding values 0.27mg/L) (CERI Hazard Data (1999), CICAD 6 (1999)), but the category could not be specified. Therefore, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From descriptions that irritation was not observed in the rabbit test and human skin application test (CICAD 6 (1999)), it was thought to be out of Category. However, from description that weak irritation is indicated on the skin (CERI hazard data (1999)), it was judged that there was slight irritation and was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B from description that mild irritation was admitted in the test applied to the eye of the rabbit of CERI Hazard Data (1999) and CICAD 6 (1999).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because CICAD 6 (1999) describes that no skin sensitization was found in the maximization test using guinea pigs.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because there are negative results from the chromosome aberration tests using rat bone-marrow cells, which are in vivo mutagenicity tests using somatic cells (CERI Hazard Data, 1999, CICAD 6, 1999).
6 Carcinogenicity Not classified - - - - Since it was classified into D according to EPA (1991) (IRIS, 2005), it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there are the discription of no effect to reproductive potential in rat reproduction study (CERI Hazard Data (1999), MOE Risk Assessment volume 1 (2002), CICAD 6 (1999), PATTY (4th, 1994), IRIS(2005)), and there is no severe reproductive toxicity in the dose causing general toxicity to parent animals in pregnancy rat oral administration test (CERI Hazard Data (1999), CICAD 6 (1999), PATTY (4th, 1994), IRIS(2005)), it is considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the descriptions that weak irritation is indicated to mucosa as the effect to human in CERI Hazard Data (1999), and that mild dyspnea was observed in the inhalation exposure test using mouse in CERI Hazard Data (1999) and CICAD 6 (1999). So it is judged that it has respiratory irritantation, therefore, it was classified into Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, respiratory system), Category 2 (kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the descriptions in CERI Hazard Data (1999), MOE Risk Assessment the 1st volume (2002), CICAD 6 (1999), ACGIH (7th, 2001), or PATTY (4th, 1994) that a liver damage, the influence on a center and the peripheral nervous system and bronchitis are reported in occupational explosure case, it was classified in Category 1 (liver, nervous systems,respiratory systems). Moreover, based on the description in CICAD 6 (1999) that the renal effects was seen in the range of guidance value of Category 2 in the oral feeding administration tests during 21 days using the rat, it was classified in Category 2 (kidney).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=360microg/L of Crustacea (Daphnia magna) (MOE Risk Assessment No.1, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 66% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=3.98 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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