GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,3,5-Triazine, hexahydro-1,3,5-trinitro-
CAS：121-82-4
Result：
| ID: | 243 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Division 1.1 |
|
Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
UNRTDG Class: 1.1D |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified in explosives |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 based on the value of LD50= 71mg/kg. This value was calculated from rat LD50: 119mg/kg (ACGIH, 7th, 2001, ATSDR1995), 100mg/kg (ACGIH, 7th, 2001, ATSDR1995), 71mg/kg (ACGIH, 7th, 2001, PATTY, 4th, 1994, ATSDR, 1995), and 300mg/kg (ACGIH, 7th, 2001, PATTY, 4th, 1994). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Skin irritation is not observed on humans (Patty (4th, 1994), ATSDR (1995)). But it caused dermatitis and erythema on rabbits and the guinea pigs, respectively (ASTDR, 1995). So it was classified as Category 3. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Insufficient data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | It is described that a repeated exposure test using guinea pigs found no sensitization (ATSDR, 1995), but no testing method is specified. Therefore we classified this as uncategorizable because of insufficient data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | The substance was regarded as outside the categories. Because the evaluation of the dominant lethality in the two-generation reproduction study in rats (ACGIH, 7th, 2001) and the in vivo dominant lethal mutagenicity test in rats (ATSDR,1995) were both negative. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | It is classified into A4 according to ACGIH (ACGIH (7th, 2001)) and is classified into C according to EPA (IRIS, 1993). So it was set as the outside of Category. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | There is a description that only the minimum effects to child are observed at the dose with which maternal toxicity develops and that no teratogenicity in the rat teratogenicity study (ACGIH (7th, 2001), IRIS (1993), and ATSDR (1995)). However, there is no other description clearly denied fertility and developmental toxicity. Therefore, it cannot be classified since data is insufficient. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, liver, kidney) |
|
Danger | H370: Causes damage to organs (nervous system, liver, kidney) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the descriptions that the confusion, motility or epileptic convulsions are observed by oral intake by accidents in human (ACGIH, 7th, 2001) and ASTDR (1995), that the nervous system symptom, such as spasm is developed in rat, miniature pig, and dog by oral administration with the range of dose of the guidance value Category 1 (ACGIH, 7th, 2001), Patty (4th, 1994) and ATSDR (1995), and that from description that swelling of the cell endoplasmic reticulum and mitochondria of liver cells and deformation of kidney tubular in oral administration study with 100mg/kg (ACGIH, 7th, 2001). So it was classified into Category 1 (a nervous system, liver, kidney) |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, hematopoietic system), Category 2 (testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, hematopoietic system) H373: May cause damage to organs through prolonged or repeated exposure (testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified in Category 1( a central nervous system, hematogenous system) based on the descriptions ; as ACGIH (7th, 2001), Patty (4th, 1994), and ATSDR (1995) noted, oversensitive symptom, insomnia, consciousness muddiness, and a spasm were seen in the poisoning case in two or more humans ; as ACGIH (7th, 2001), IRIS (2006), and ATSDR (1995) noted, a tremor, convulsion onset, a necrosis of megakaryocytes in marrow and a spleen, and the appearance of hemosiderin were seen in the 90-day repetition oral administration using cynomolgus with 10mg/kg/day, and oversensitive symptom and a spasm were seen with 25mg/kg/day in the feeding administration for 12 weeks using the rat ; as ACGIH (7th, 2001), Patty (4th, 1994), IRIS (2006), and ATSDR (1995) noted, the same symptom was seen with 50mg/kg/day by six-week repetition oral administration with a dog. Moreover, it was classified in Category 2 (testis) from description in IRIS (2006) that the denaturation of the testis was seen with 35mg/kg/day by the feeding administration tests for 24 months using a mouse. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96-hour LC50=12.7mg/L of fishes (Fathead minnows) (ECETOC TR91, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Based one NOEC=1.4 mg/L during 28 days of the fish (fathead minnows) (ECETOC TR91, 2003), though acute toxicity was Category 3. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |