GHS Classification Result

Chemical Name：Zinc sulphate
CAS：7733-02-0

Result：
ID: 247
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (HSDB, 2006)
8 Self-reactive substances and mixtures Not classified - - - - The kick-off temperature is considered to exceed 75degC. According to HSDB (2006), anhydrous zinc sulfate forms when its hydrates are heated above 238degC, and at about 680degC, SO3 separates from the compound, forming 3ZnO.2SO3.
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (HSDB, 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (HSDB, 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 57.75g/100g (25degC), Lide (84th, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 1,260mg/kg calculated from the testing data of rat LD50 (oral route) of 1,710mg/kg (CERI Hazard Data 98-1 (1999), EHC 221 (2001)), 2,940mg/kg (CERI Hazard Data 98-1 (1999), EU-RAR No.46 (2004)), 920mg/kg and 2,280mg/kg (EU-RAR No.46 (2004)). These data might probably refer to hydrates, and not anhydrides. Note: As for the classification of 7-hydrate, refer to "ID1108, CAS# 7446-70-0."
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available. Note: As for the classification of 7-hydrate, refer to "ID1108, CAS# 7446-70-0."
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available Note: As for the classification of 7-hydrate, refer to "ID1108, CAS# 7446-70-0."
2 Skin corrosion/irritation Classification not possible - - - - No data available. Note: As for the classification of 7-hydrate, refer to "ID1108, CAS# 7446-70-0."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (exposure duration unknown) (EU-RAR No.46 (2004)): "Yellow/white spots were observed in the tissue of the lower eyelid, nictitating membrane and/or sclera in all animals from day 7 until termination. These spots were described as signs of necrosis," "severe ocular irritation." Also based on the description of the human health effects (CERI Hazard Data 2001-29 (2002)): "The substance produced grayish pigmentation of the cornea, leaving the crystalline lens spotted after recovery." The substance is thus considered to be a very strong irritant. These data might probably refer to hydrates. Note: As for the classification of 7-hydrate, refer to "ID1108, CAS# 7446-70-0."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the description in the report on guinea pig skin sensitization tests (EU-RAR No.46 (2004)): "Zinc sulphate is not considered a skin sensitization." Also based on the description in the report on mouse skin sensitization tests (IUCLID (2000)): "Not sensitizing."
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests and chromosome aberration tests), described in ATSDR (2005), EU-RAR No.46 (2004), EHC 221 (2001) and CERI Hazard Data 2001-29 (2002).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification (though some toxicity data are available).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of adverse effects on reproduction/development (decreased male/female fertility and implantation), described in EU-RAR No.46 (2004), ATSDR (2005) and EHC 221 (2001) (though no data are available regarding parental toxicity).
8 Specific target organ toxicity - Single exposure Category 1 (kidney, liver, respiratory system) Danger H370: Causes damage to organs (kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "... the kidneys were damaged and proteinuria, glucosuria and acetonuria were detected," "... vomiting, diarrhea, jaundice, oliguresis were noted; autopsy findings consisted of renal tubular necrosis, hyaline membrane in the lung and changes in the liver" (CERI Hazard Data 2001-29 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (pancreas, adrenal gland, cardiovascular system) Danger H372: Cause damage to organs through prolonged or repeated exposure (pancreas, adrenal gland, cardiovascular system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "islet cell hypertrophy and betacell vacuolization were observed," "hypertrophy of suprarenal cortical cells, and increased lipid" (ATSDR (1980)), "obstructive vascular disease" (ATSDR (1980)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.061mg/L(Zinc Sulfate Equivalent=0.151mg/L) of the fish (Cutthroat Trout) (EHC221, 2001).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since although acute toxicity was Category 1 and bio-accumulation was low (BCF=242 (existing chemical safety inspections data)), it was a metallic compound, and the underwater action was unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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