GHS Classification Result

Chemical Name：Diantimony trioxide
CAS：1309-64-4

Result：
ID: 250
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,2003)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,2003)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,2003)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 1.4mg/100mL (30degC), (ICSC, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to the absence of data, though being inorganic compounds containing oxygen.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the description in the report on human epidemiological studies (CERI Hazard Data 2001-7 (2002)): Acute effects on human health are observed, with fatal cases reported.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - "Irritative" according to EU Risk Phrase (2005), but data that can serve as evidence are unknown.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the evidence of "mild irritation" from rabbit eye irritation tests (CERI-NITE Hazard Data 2001-7 (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests, negative data on germ cell multi-generation mutagenicity tests in vivo (chromosome aberration tests), somatic cell mutagenicity tests in vivo (chromosome aberration tests) show negative (the results of a single administration show negative, while those of 21-day administration show an increase in the incidence of bone marrow chromosome aberrations). The judgment conforms to that of experts (i.e., classification based on the information obtained from the search of literatures). described in PATTY (4th, 2000) CERI Hazard Data 2001-7 (2002), IARC 47 (1989).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A2 by ACGIH (2001).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rat teratogenicity and reproductive toxicity tests (IARC 47 (1989)): Infertility and an increase in absorbed embryos (during pre- and post implantation stages) are observed at dosing levels not toxic to dams. The judgment conforms to that of experts: Although the substance could be classified into Category 2 based solely on the results of animal studies, Category 1B should be appropriate because epidemiological data are not considered "reliable enough to provide evidence for the classification into Category 1A."
8 Specific target organ toxicity - Single exposure Category 1 (heart), Category 2 (respiratory system) Danger
Warning 		H370: Causes damage to organs (heart)
H371: May cause damage to organs (respiratory system) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		Based on the human evidence including "a total of fifty-six inpatients developed burning pain in the stomach, colicky pain and nausea" (IRIS 6 (1987)), "heart muscle necrosis was observed in autopsy specimens" (CERI Hazard Data 2001-7 (2002)), and the evidence from animal studies including "mild and local discoloration of the lungs, white protuberant lesions" (CERI Hazard Data 2001-7 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. Refer to the GHS classification of Antimony Chloride (Antimony Trichloride) (CAS 10025-91-9).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In humans, many observations are reported. Some of them are; "chest X-rays revealed pneumonitis", "workers were found to have antimony pneumoconiosis and were suspected of having pneumoconiosis", "(Author) reported a correlation between the degree of radiographic abnormalities, amount of antimony retained in the lungs, and duration of exposure", "the presence of diffuse, densely distributed punctate opacities having a diameter <1 mm and concentrated in the mid-lung region". In experimental animals, some of the reported observations are as follows; "Gross necropsy revealed lung discoloration ", lesions of the lungs observed included particle-laden macrophages, degenerating macrophages, and cellular debris in the lumen of the alveoli", "interstitial fibrosis, alveolar-wall cell hypertrophy and hyperplasia", "granulomatous inflammation and granulomas"(IRIS (2002)) and "a decrease in body weights, interstitial fibrosis, alveolar-wall cell hypertrophy and hyperplasia, cuboidal and columnar cell metaplasia of the lungs, and cholesterol clefts (CERI Hazard Data Book for Chemical Substances 2001-7 (2002)). Based on these observations, the respiratory organs and gastrointetinal tract are considered to be the target organs. The effects are observed within the guidance values for Category 1. Therefore, the substance was classified as Category 1 (respiratory system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72 hours EC50=67mg/L of the algae (Selenastrum) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 3 and it was a metallic compound and an underwater action and bio-accumulation were unknown, it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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