GHS Classification Result

Chemical Name：Cadmium chloride
CAS：10108-64-2

Result：
ID: 254
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,1999)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,1999)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,1999)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 140g/100mL (20degC), HSDB (2006))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to the absence of data, though being inorganic compounds containing chlorine.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the testing data of 88mg/kg representing the lowest value of rat LD50 (oral route) of 88-302mg/kg (CaPSAR (1994)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in HSDB (2005) of the human health effects: Short-term exposure causes smarting of the skin and first degree burns. The substance is considered "irritating" to the skin, although should be placed in Category 2 from the viewpoint of safety.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in IARC 58 (1993), multi-generation mutagenicity tests (dominant lethal tests, translocation tests) generally show negative; germ cell mutagenicity tests in vivo show weak negative (aneuploidy is detected in oocytes and sperm mother cells); somatic cell mutagenicity tests in vivo (chromosome aberration tests, micronucleus tests) show positive.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category K (as cadmium and cadmium compounds) by NTP (2005), Group 1 (as cadmium and cadmium compounds) by IARC (1993) and Category 1 (as cadmium and cadmium compounds) by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rat and mouse teratogenicity tests (ATSDR (1999), CaPSAR (1994), IARC 58 (1993)): an increase in the incidence of abnormal sperm, a delay in the growth of the embryo, a decrease in copulation rates, seminiferous tubule necrosis.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver, testis) Danger H370: Causes damage to organs (respiratory system, liver, testis) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "damage to the liver (ATSDR (1999)), and the evidence from animal studies including "pulmonary edema, pneumonia, alveolar cell damage and necrosis (Type 1), focal degeneration/necrosis of parenchyma cells, necrosis of the testes" (ATSDR (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. And based on the human evidence including "acute toxicity following inhalation (chemical pneumonia, pulmonary edema) and ingestion (acute/severe nausea, vomiting, gastralgia)" (EHC 134 (1992)) (cadmium compounds).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, bone, liver, kidney, blood system, heart) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, bone, liver, kidney, blood system, heart) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "pulmonary inflammation, induction of hyperplastic changes in the lungs" (CaPSAR (1994)), "changes in calcium metabolism, osteomalacia (EHC 61 (1988)), necrosis of centrilobular hepatocytes and renal tubules, anemia, myocardial congestion, muscle fiber separation" (ATSDR (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.00205mg/L of the crustacea (Mysid Shrimp)) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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