GHS Classification Result

Chemical Name：Chromium trioxide
CAS：1333-82-0

Result：
ID: 261
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2003)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2003)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2003)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 167.299Lb/100Lb (21degC)[converted to 167.299g/100g(21degC)], HSDB (2006))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified as "Division 5.1: oxidizing substances" by UN Recommendations on the Transport of Dangerous Goods. It can, however, be included in Category 2 or 3, given the fact that it has subsidiary risks corresponding to Division 6.1 and Class 8 and is assigned to Packing Group II (UN#1493). The substance is placed in Category 2 from the viewpoint of safety.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 97-18 (1998)): "severe irritation" (though it is unclear whether the results are those of 4-hour application), and the human evidence of "chemical burn and necrosis over a large area of the arm" after accidental exposure (ATSDR (2000)). The substance is thus considered to cause "skin corrosion." Although classified into 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety, if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in EU-RAR No.53 (2005) of the effects on human health: Accidental exposure to water-soluble Cr (VI) solution causes damage to the eyes; A number of case reports indicate corneal/conjunctival inflammation and severe symptoms such as corneal erosion and ulceration; Single and repeated exposure causes severe, persistent damage to the eyes and skin associated with the formation of ulcers. Chromic anhydride is classified into Category 1, according to the classification of chromium (VI) compounds into the same category. As for the health hazards, refer to the data on chromium and chromium compounds.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Based on the description in CERI Hazard Data 97-18 (1998) of the human health effects: "Inhalation of fume causes bronchial asthma." Chromium is classified into "Respiratory Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy, and "Respiratory Sensitizing Substance: Group 2"* by the Japan Society for Occupational Health. These classifications, though not specifying chromic anhydride, seem to include chromium compounds. Chromic anhydride, which is a chromium compound, should thus cause respiratory sensitization. * There is a provision to the effect that "the category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Chromium is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy, and "Skin Sensitizing Substance: Group 1"* by the Japan Society for Occupational Health. These classifications, though not specifying chromic anhydride, seem to include chromium compounds. Chromic anhydride, which is a chromium compound, should thus cause skin sensitization. * There is a provision to the effect that "the category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in ATSDR (2000), IARC 49 (1999) and EHC 61 (1988).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category 1 by EU (2005), Group 1 (as Chromium (VI)) by IARC (1990), Category K (as Chromium hexavalent (VI) compounds) by NTP, Category 1 (Chromium hexavalent (VI) compounds)by the Japan Society for Occupational Health.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available As for the reproductive toxicity of Cr (IV), refer to potassium dichromate (CAS: 7778-50-9).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available The acute toxicity of hexavalent chromium compounds manifests as "cough, yellow-green phlegm, dyspnea, pulmonary congestion, vomiting (yellow-green mucus), gastralgia, diarrhea, nausea, vomiting, hepatic damage, renal damage" (CERI Hazard Data 97-18 (1998)). Refer to the GHS classification result of potassium dichromate (ID 0262, CAS 7778-50-09).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "nasal septum perforation, bronchial asthma" (CERI Hazard Data 97-18 (1998)), and the evidence from animal studies including "nasal septum perforation, inflammation of trachea and bronchus, and squamous metaplasia." The effects were observed at dosing levels within the guidance value ranges for Category 1. The chronic toxicity of hexavalent chromium compounds manifests as "nasal mucosa, inflammation and ulcers in the pharynx and larynx, nasal septum perforation" (CERI Hazard Data 97-18 (1998)). Refer to the GHS classification result of potassium dichromate (ID 0262, CAS 7778-50-09).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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