GHS Classification Result

Chemical Name：o-Chloroaniline
CAS：95-51-2

Result：
ID: 267
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 108degC (open cup flash test) (ICSC, 2001)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 500degC (ICSC, 2000)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1(UN#2019, Chloroaniline (liquid)) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 1,016mg/kg (CERI Hazard Data 99-25 (2000)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 1,000mg/kg (CERI Hazard Data 99-25 (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the LC50 value (4 hours) of 2.02mg/L (equivalent to 388ppm), calculated from the testing data of rat LC50 (1 hour) of 775ppm (CERI Hazard Data 99-25 (2000)), and the LC50 (4 hours) of 4.16mg/L (MOE Risk Assessment vol.3 (2004)) exceeded the saturated vapour concentration (350ppm) under a saturated vapour pressure of 35Pa (25degC), the substance was considered as "mist exposure" and was classified based on the LC50 (4 hours) value of 2.02mg/L representing the lower of the two data.
2 Skin corrosion/irritation Not classified - - - - Based on the description in the report on rabbit skin irritation tests (4 hours) performed in accordance with OECD Test Guideline 404 (CERI-NITE Hazard Assessment No.58 (2004)): "non-irritating to the skin."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests: "Mild eye irritation was induced, with recovery observed within 3-7 days of exposure" (CERI-NITE Hazard Assessment No.58 (2004)).
4 Respiratory sensitization Classification not possible - - - - Classification not possible
4 Skin sensitization Classification not possible - - - - Classification is not possible because of the insufficiency of data, although guinea pig Maximization tests show negative results for sensitization (CERI-NITE Hazard Assessment No.58 (2004)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in CERI-NITE Hazard Assessment No.58 (2004).
6 Carcinogenicity Classification not possible - - - - Cannot be classified given the insufficiency of data for use in classification, along with the absence of existing classification.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in MOE Risk Assessment vol.3 (2004): The results of rat teratogenicity tests suggest a significant increase in early resorptions, a significant decrease in viable fetuses and an increase in the incidence of spontaneous malformation in pups at doses causing maternal toxicity.
8 Specific target organ toxicity - Single exposure Category 1 (blood system, central nervous system, heart, liver, kidney) Danger H370: Causes damage to organs (blood system, central nervous system, heart, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "headache, coughing, vomiting, thirst, delirium, ataxia, dizziness, ear noise, disorientation, debility, lethargy, coma, cardiac block, cardiac dysrhythmia, shock, circulatory disorder, painful urination, bloody urine, hemoglobinuria, kidney damage" (CERI Hazard Data 99-25 (2000)), "methemoglobinemia, liver and kidney damage" (MOE Risk Assessment vol.3 (2004)), and the evidence from animal studies including "increased blood methemoglobin concentrations and cyanosis" (NITE Initial Risk Assessment No.58 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system), Category 2 (central nervous system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system)
H373: May cause damage to organs through prolonged or repeated exposure (central nervous system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "increased blood methemoglobin concentration, cyanosis, tremor and increased Heinz bodies" (NITE Initial Risk Assessment No.58 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (blood system), and Category 2 (central nervous system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours LC50=0.13mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=32(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 2.7%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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