GHS Classification Result

Chemical Name：Chloroacetic acid
CAS：79-11-8

Result：
ID: 268
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Cannot be classified due to lack of data, though "flammable" according to ICSC (2003). Classified into Division 6.1 and Class 8, in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#0154, chlorodinitrobenzene (solid)).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 470degC (ICSC, 2003)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 52.5-63degC (ICSC,1999), test temperature:140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (melting point: 63degC (alpha type), 56.2degC (beta type) (ICSC, 2003), test temperature: 55degC). No data available (melting point: 52.5degC (gamma Type) (ICSC, 2003)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 55mg/kg calculated from the testing data of rat LD50 (oral route) of 55mg/kg, 90mg/kg and 277.5mg/kg (EU-RAR No.52 (2005)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 250mg/kg representing the lower of the testing data of rat LD50 (dermal route) of 305mg/kg and rabbit LD50 of 250mg/kg (EU-RAR No.52 (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of "severe irreversible irritation and corrosion of the skin" in rabbit skin irritation tests (though the results are not those of 4-hour application) (CERI Hazard Data 98-9 (1999)) and the epidemiological evidence of "chemical burn at the site of exposure." Although classified as Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety, if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence of "severe eye irritation (severe eye corrosion)" in rabbit eye irritation tests (EU-RAR No.52 (2005)) and the epidemiological evidence of "serious eye irritation and corrosion" (CERI Hazard Data 98-9 (1999)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Cannot be classified due to the insufficiency of data
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and negative data on somatic cell genotoxicity tests in vivo (DNA damage tests), no strong positive data on mutagenicity tests in vitro, described in EU-RAR No.52 (2005) and NTP DB (Access on February 2006).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as A4 by ACGIH (2005).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in MOE Risk Assessment vol.3 (2004), EU-RAR No.52 (2005) and BUA 127 (1993): The results of rat teratogenicity tests suggest a significant increase in the incidence of heart malformation in fetuses at dosing levels toxic to parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, heart, kidney, liver, respiratory system) Danger H370: Causes damage to organs (nervous system, heart, kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "nausea, vomiting, cardiovascular system disorder, nervous system disorder including loss of consciousness and coma" (CERI Hazard Data 98-9 (1999)), "disorientation, excitement, heart failure and coma, severe metabolic acidosis, rhabdomyolysis, hepatic adipose infiltration, renal failure and brain edema, severe respiratory irritation and pulmonary edema" (MOE Risk Assessment vol.3 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, heart, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, heart, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "peripheral pulmonary perivenous infiltration and wall thickening" (CERI Hazard Data 98-9 (1999)), "myocardial degeneration, chronic nasal inflammation, moderate liver inflammation" (MOE Risk Assessment vol.3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours ErC50=0.033mg/L of the algae (Scenedesmus) (CERI/NITE Hazard Assessment Report (preliminary version), 2006).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 99.8% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.22 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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