Chemical Name：2',4-Dichloro-alpha,alpha,alpha-trifluoro-4'-nitro-m-toluenesulfonanilide; Flusulfamide
CAS：106917-52-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the LD50 (oral route) value of 132mg/kg in rat acute toxicity studies (Agricultural Chemical Registration Data (1990)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the absence of mortality at the highest dose of 2,000mg/kg in rat acute toxicity studies using the dermal route of exposure (Agricultural Chemical Registration Data (1990)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the dog LC50 (4 hour inhalation) value of 0.079mg/L (Agricultural Chemical Registration Data (1990)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Rabbit skin irritation tests yielded a mean Draize score of 0.09, suggesting little potential for irritation (Agricultural Chemical Registration Data (1990)).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the evidence of severe irritation with effects persisting in one of six test animals after day 7, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1990)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on negative results obtained in guinea pig skin sensitization tests using the Buehler method (Agricultural Chemical Registration Data (1990)).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification is not possible due to lack of data on in vivo studies, though negative results were reported in several in vitro studies (reverse mutagenicity tests, DNA repair tests and chromosome aberration tests) (Agricultural Chemical Registration Data (1990)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related evidence of tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1990)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The available rat reproductive toxicity studies and rat/rabbit teratogenicity studies provide slight evidence of reduced pup viability and visceral/skeletal anomalies at doses inducing reduced body weight gains in parental animals (Agricultural Chemical Registration Data (1990)). Since it cannot be clearly demonstrated that the findings of pup effects are secondary to parental toxicity, the substance is classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In the available rat oral studies, clinical signs and symptoms including mydriasis, abnormal gait, sedation, lacrimation, tremors and emaciation were found (Agricultural Chemical Registration Data (1990)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the available rat repeated dose toxicity studies, clinical signs and symptoms including vacuolization of myelinated nervous tissue of the central nervous system, increased gamma-GTP/GOT/ bilirubin concentrations, and hypertrophy of centrolobular hepatocytes were found (Agricultural Chemical Registration Data (1990)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.29mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.8(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.