GHS Classification Result

Chemical Name:O,O-Dimethyl S-(N-methylcarbamoyl)methyl phosphorodithioate; Dimethoate
CAS:60-51-5

Result:
ID: 279
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (1999). Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC (1999)) (UN Recommendation on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC (1999)) (UN Recommendation on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC (1999)) (UN Recommendation on the Transport of Dangerous Goods).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 15.9g/L (20degC), Agricultural Chemical Registration Data).
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being organic compounds containing oxygen (but not chlorine and fluorine) bound to the elements other than carbon and hydrogen
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available on substances with melting point of <55degC (melting point: 47.5-49.3degC, Agricultural Chemical Registration Data).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral roue) value of 255mg/kg (Agricultural Chemical Registration Data (1986)).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the mouse LD50 (dermal route) value of 310mg/kg (Agricultural Chemical Registration Data (1986)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The available rat inhalation studies yielded the LC50 (4 hour) value of >0.900mg/L (Agricultural Chemical Registration Data (1986)). However, classification is not possible because there is no evidence of death at the highest dose of 0.900mg/L, and the acute toxicity value cannot be determined.
2 Skin corrosion/irritation Not classified - - - - Based on no evidence of irritation reported in several skin irritation studies with rabbits (Agricultural Chemical Registration Data (1985)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1985)): "The substance caused mild irritation, with effects clearing up by day 7 in all affected animals."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on a positive rate of 0% for guinea pig Buehler tests (Agricultural Chemical Registration Data (1984)) and 25% for Maximization assays (Agricultural Chemical Registration Data (1984)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data on mouse dominant lethal tests, chromosome aberration tests on somatic cells in vivo and mouse micronucleus tests in vivo, though positive results were reported in reverse mutation tests in vitro and chromosome aberration tests on CHL cells in vitro (Agricultural Chemical Registration Data (1985)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1986). Also due to the fact that the substance is classified as Group C by EPA (1992).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproductive function/capacity and pup development observed in rat 3-generation reproduction studies (Agricultural Chemical Registration Data (1965)) and gestation studies in rats and rabbits (Agricultural Chemical Registration Data (1984)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In the available rat and mouse single dose toxicity studies, clinical signs and symptoms including muscular fasciculations, reduced locomotor activity, staggering gait, limb paralysis, loss of righting reflex, irregular respiration, dyspnea, lacrimation, chromodacryorrhea, salivation, incontinence, soft feces, diarrhea, pupillary constriction, piloerection, exophthalmos, and reduced body weight (males) have been reported (Agricultural Chemical Registration Data (1986)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
The nervous system is considered to be the target organ based on the observations in animal studies including unkempt fur and piloerection, and exophthalmos with pale eyes in female (Technical Reports forAgricultural Chemical Registration (1961, 1967)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Therefore the substance has been classified as Category 1 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48 hours EC50=2mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=0.8(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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