Chemical Name：2,3-Dihydro-2,2-dimethyl-7-benzo[b]furyl N-(dibutylamino)thio-N-methylcarbamate; Carbosulfan
CAS：55285-14-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 101mg/kg (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (dermal route) value of 4,012mg/kg (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation exposure) value of 0.15mg/L (4 hours) (Agricultural Chemical Registration Data (1981)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the evidence of only mild irritation (the highest Draize score of 1.2), with effects fully clearing up within 6 days, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1981)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In the available rabbit eye irritation tests, irritation reactions were found only in the conjunctiva, and the effects fully cleared up by day 3 (Agricultural Chemical Registration Data (1981)). The substance is thus considered a mild eye irritant.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the description in the report on guinea pig skin sensitization studies (Agricultural Chemical Registration Data (1981)): "The substance induced mild skin sensitization."
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutation tests (several indices) (Agricultural Chemical Registration Data (1981)), in vivo mouse somatic cell micronucleus tests (Agricultural Chemical Registration Data (1982)) and in vivo rat chromosome aberration tests (Agricultural Chemical Registration Data (1981)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in 2-year (rats) (Agricultural Chemical Registration Data (1982)) and 18-month (mice) (Agricultural Chemical Registration Data (1982)) carcinogenicity studies.
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on parental reproduction and offspring development in rat 3-generation reproductive toxicity studies (Agricultural Chemical Registration Data (1982)) and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1981)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, gastrointestinal tract)		Danger	H370: Causes damage to organs (nervous system, gastrointestinal tract)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including reduced locomotor activity, tremors, back muscle fasciculation, salivation, lacrimation, splinter hemorrhage of the fundus were reported (Agricultural Chemical Registration Data (1981)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the available rat repeated dose toxicity studies, decreased hematocrit levels, low lymphocyte levels and high segmented cell levels were detected (Agricultural Chemical Registration Data (1981)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.00103mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.57 (PHYSPROP Database, 2005)), it was classified into Category 1.