Chemical Name：Ethyl 2-[(dimethoxyphosphinothioyl)thio]-2-phenylacetate; Phenthoate; PAP
CAS：2597-03-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 249mg/kg (Agricultural Chemical Registration Data (1978)).
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the mouse LD50 (dermal route) value of 2,620mg/kg (Agricultural Chemical Registration Data (1966)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LC50 (inhalation route) value of 3.17mg/L (Agricultural Chemical Registration Data (1980)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1978)): Non-irritating to the skin.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1975)): Non-irritating to the eye.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on a sensitization rate of 0% reported in guinea pig skin sensitization studies using the Buehler method (Agricultural Chemical Registration Data (1990)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1989)), in vitro reverse mutation tests (Agricultural Chemical Registration Data (1976)) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (2004)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1991).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of increased pup death at doses causing adverse effects on parental animals in rat 2-generation reproduction studies (Agricultural Chemical Registration Data (1987)). Since it cannot be clearly demonstrated that the pup mortality is secondary to parental toxicity, the substance is classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including reduced locomotor activity, tremors, salivation, lacrimation and clonic convulsions were reported (Agricultural Chemical Registration Data (1978)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In rat repeated dose toxicity studies, an increase in white blood cell counts, a decrease in acidophile/red blood cell counts, and vacuolization of centrolobular hepatocytes were found (Agricultural Chemical Registration Data (1973)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.00025mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2005).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (BCF=34(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.