GHS Classification Result

Chemical Name:Mercury diacetate
CAS:1600-27-7

Result:
ID: 284
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2000)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2000)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2000)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 40g/100mL (20degC), ICSC (2000))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to carbon and hydrogen. Classified into Division 6.1 (UN#1629) (UN Recommendations on the Transport of Dangerous Goods)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 41mg/kg (RTECS (2005)).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rabbit LD50 (dermal route) value of 570mg/kg (RTECS (2005)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in ICSC (J) (2000): The substance causes "skin burn and pain; Corrosive to the eye/skin/respiratory tract; Oral ingestion produces corrosive effects." The substance is thus considered corrosive to the skin and classified into Category 1A-1C. However, it should be placed in Category 1, if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in ICSC (J) (2000): The substance causes "skin burn and pain; Corrosive to the eye/skin/respiratory tract; Oral ingestion causes corrosive effects." The substance is thus considered corrosive to the skin and classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Mercury is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy, and "Skin Sensitizing Substance: Group 1"* by the Japan Society for Occupational Health. These classifications, though not specifying mercury acetate, seem to include mercury compounds. Mercury acetate, which is a mercury compound, should thus cause skin sensitization. * There is a provision to the effect that "the category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on positive data on somatic cell mutagenicity tests in vivo and the absence of data on germ cell genotoxicity in vivo. Positive results (as mercury compounds) are also available in multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, but not used for effects assessment.
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 (as metal mercury and inorganic mercury compounds) by ACGIH (2001) and Group 3 (as metal mercury and inorganic mercury compounds) by IARC (1993).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of adverse developmental effects on pups (though no data are available on maternal toxicity), described in ATSDR (1999), CICAD 50 (2003) and EHC 118 (1991). As for the reproductive toxicity of inorganic mercury compounds, refer to "ID285, Mercury Chloride (II), CAS 7487-94-7."
8 Specific target organ toxicity - Single exposure Category 2 (kidney, respiratory system) Warning H371: May cause damage to organs (kidney, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in ICSC (J): the substance causes "corrosion of the respiratory tract; oral ingestion causes corrosion; may adversely affect the kidney" (ICSC (J) (2000)). Classified as priority 2 by ICSC (J). Note: According to CICAD 50 (2003), "renal failure, cardiovascular collapse and severe digestive organ damage are considered to be the causes of death following oral exposure to inorganic mercury. Most common findings among these are gastrointestinal tract lesion and renal failure. Exposure to inorganic mercury appears to induce nephrotic syndrome in humans."
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (nervous system) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (nervous system)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description in ICSC (J): the substance "adversely affects the central/peripheral nervous systems and kidney, may cause ataxia, sense/memory disorder, tremor, muscular weakness and kidney damage" (ICSC (J) (2000)). Also based on the evidence from animal studies: "partial hypertrophy and dilation of proximal renal tubules were initially observed, which progressed to increased dilation, hyaline cast, fibrosis and inflammation, and resulted eventually in cyst, extensive fibrosis and alterations in the glomerulus" (ATSDR (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Classified as priority 2 by ICSC. Note: According to CICAD 50 (2003), "renal failure, cardiovascular collapse and severe digestive organ damage are considered to be the causes of death following oral exposure to inorganic mercury. Most common findings among these are gastrointestinal tract lesion and renal failure. Exposure to inorganic mercury appears to induce nephrotic syndrome in humans."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.06mg/L of the crustacea (Glass Shrimp) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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