Chemical Name：O,O-Diethyl O-2-quinoxalinyl phosphorothioate; Quinalphos
CAS：13593-03-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 51mg/L (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (dermal route) value of 850mg/L (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation route) value of 0.45mg/L (Agricultural Chemical Registration Data (1983)).
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1983)): "Slight erythematous responses were noted at 24 hours. By 72 hours, the reactions cleared up" (though the Draize score is not presented).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1983)): "Non-irritating to the eye."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on no evidence of skin sensitization observed in guinea pig skin sensitization studies (Agricultural Chemical Registration Data (1980)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutation tests, in vitro chromosome aberration tests, in vivo micronucleus tests on mouse somatic cells and in vivo chromosome aberration tests on rat somatic cells (Agricultural Chemical Registration Data (1983)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1992).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of parental reproduction and pup development toxicity observed in rat 3-generation reproduction studies (Agricultural Chemical Registration Data (1983)) and rabbit/rat teratogenicity studies (Agricultural Chemical Registration Data (1983, 1992)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including crouching position, tremors, relaxation, salivation and incontinence (Agricultural Chemical Registration Data (1983)). The effects on the nervous system were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In animal studies, plasmic/corpusclar cholinesterase inhibition and increased liver weight were observed. However, classification is not possible due to lack of data, since no evidence of other common symptoms or histopathological abnormalities was reported (Agricultural Chemical Registration Data (1983)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours LC50=0.124microg/L of the crustacea (Penaeus Monodon) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.44 (PHYSPROP Database, 2005)), it was classified into Category 1.