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GHS Classification Result

Chemical Name：O,O-Dimethyl S-2-[1-(N-methylcarbamoyl)ethylthio]ethyl phosphorothioate; Vamidothion
CAS：2275-23-2

Result：


ID:	297
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Not classified	-	-	-	-	Classified as flammable according to ICSC (2002). Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC, 2002)) (UN Recommendation on the Transport of Dangerous Goods).
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Not classified	-	-	-	-	Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC, 2002)) (UN Recommendation on the Transport of Dangerous Goods).
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC, 2002)) (UN Recommendation on the Transport of Dangerous Goods).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (water solubility: 1*10^(6)mmHg (20degC), SRC (2006))
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not classified	-	-	-	-	No data available, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen. Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC, 2002)) (UN Recommendation on the Transport of Dangerous Goods).
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Not classified	-	-	-	-	Classified into Division 6.1 (UN#2783 Organophosphorous Pesticide, solid, toxic (ICSC, 2002)) (UN Recommendation on the Transport of Dangerous Goods).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 64mg/kg representing the lower of the two testing data, 64mg/kg (HSDB (2006)) and 105mg/kg (HSDB (2006)).
1	Acute toxicity （Dermal）	Category 4		Warning	H312: Harmful in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the rabbit LD50 (dermal route) value of 1,160mg/kg (RTECS (2006)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LC50 (inhalation of dust/mist) value of 1.730mg/L (4 hours) (RTECS (2006)).
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Based on the absence of data on in vivo tests and only slightly positive data on two in vitro tests
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "tremor and spasm" (RTECS (1998)), "adversely affects the nervous system; may induce spasm and respiratory failure; at high doses, death may occur" (ICSC (J) (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Since all referenced studies are assigned a priority rating of 2, the effects are classified into Category 2.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies: "in several instances, gait disorder due to rigidity of the hind limbs was observed" (PESTICIDE RESIDUES IN FOOD - 1988). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	Classification not possible due to lack of data

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）