GHS Classification Result

Chemical Name：Copper dichloride
CAS：7447-39-4

Result：
ID: 298
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (HSDB, 2006)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (HSDB, 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (HSDB, 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 73parts/100parts(20degC), HSDB(2006))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being inorganic compounds containing chlorine. Classified into Class 8 (UN#2802) (UN Recommendations on the Transport of Dangerous Goods)
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 140mg/kg (EHC 200 (1998)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in EHC 200 (1998) of the human health effects of copper (though no data are available on copper chloride per se): "These data provide suggestive evidence that copper may be irritative to the skin." The substance is thus considered a skin irritant (though the severity of the effects is unknown), and hence can be classified into Category 2 or 3. However, it should be placed in Category 2 from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of "severe effects" from the rabbit eye irritation tests (HSDB (2005)), and the human evidence (EHC 200 (1998)): "Eye irritation was observed among workers occupationally exposed to copper dust." The substance is thus considered irritating to the eye (though the severity of the effects is unknown) and classified into 2A-2B. It should be placed in Category 2A from the viewpoint of safety, if further subclassification is needed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in EHC 200 (1998) of the effects on human health: "Copper and its salts may induce allergic dermatitis. Clinical signs include smarting, reddening, swelling, formation of vesicles and pustules." Also due to the fact that copper is classified into "Skin Sensitizing Substance" by the Japanese Society of Occupational Allergy, and "Skin Sensitizing Substance: Group 2"* by the Japan Society for Occupational Health. These classifications, though not specifying copper chloride, seem to include copper compounds. Copper chloride, which is a copper compound, should thus cause skin sensitization. * There is a provision to the effect that "the category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no strong positive data on mutagenicity tests in vitro (with some negative results), described in EHC 200 (1998) and ATSDR (2004). As for the health hazards, refer to "ID850, Copper, CAS: 7440-50-8."
6 Carcinogenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID850, Copper, CAS: 7440-50-8."
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		No data on female reproductive toxicity were identified. However, the study results reported in EHC 200 (1998) suggest adverse effects on sperm production in males, though no information is provided for general toxicity. As for the health hazards, refer to "ID850, Copper, CAS: 7440-50-8."
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available The acute toxicity of copper compounds manifest as "vomiting, lethargy, acute hemolytic anemia, kidneys/liver damage, neurotoxicity, elevated blood pressure/respiratory rate, coma and death" (EHC 200 (1998)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available The chronic toxicity of copper compounds manifest as "retching, abdominal pain, vomiting, abdominal pain, vomiting and diarrhea" (EHC 200 (1998)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.001mg/L of the crustacea (Marsupenaeus Japonicus) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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