GHS Classification Result

Chemical Name：Copper(II) sulfate, pentahydrate
CAS：7758-99-8

Result：
ID: 300
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not classified - - - - According to Chemical Dictionary (1994), the hydrate form can be dehydrated by heating (3-hydrate when heated at 30degC, 1-hydrate at 110degC, anhydride at 250degC). The kick-off temperature is considered to exceed 75degC.
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 22.05g/100g (25degC) (anhydride equivalent), Lide (84th, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing oxygen
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 960mg/kg (EHC 200 (1998)).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data. The substance can be "Not classified" or classified into "Category 5" based on the available data (rat LD50 of >2,000mg/kg (dermal route)) (RTECS (2006)). If the study is conducted in accordance with OECD Guideline which specifies the upper limit at 2,000mg/kg, it is reasonable to consider the substance to be "Not classified" unless "there arises an urgent concern to human health," because no study is expected to be conducted with larger doses. However, "classification is not possible" since, in this study report, only numerical results are provided and study details are not available (the priority rating for the study is 2).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on human epidemiological studies (ICSC (2001)): "Causes redness and pain" (though the severity of the effects is unknown). The substance is thus considered a skin irritant.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on human epidemiological studies (ICSC (2001)): "Causes pain, redness and dimness of sight" (though the severity of the effects is unknown). Although classified into Category 2A-2B, the substance should be placed in Category 2A from the viewpoint of safety if further subclassification is needed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified into "Group 2" (as copper and its compounds) by the Japan Society for Occupational Health, and a "Skin Sensitizing Substance" (as copper) by the ad hoc committee of the Japanese Society of Occupational Allergy (2004).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in NTP DB (Access on July, 2006), ATSDR (2004) and EHC 200 (1998).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification (though some toxicity data are available).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of malformation and adverse effects on postnatal development of pups, described in ATSDR (2004), EHC 200 (1998) and CERI Hazard Data 2001-59 (2002) (though no data are available regarding parental animals).
8 Specific target organ toxicity - Single exposure Category 1 (blood system, liver, nervous system, kidney, respiratory system) Danger H370: Causes damage to organs (blood system, liver, nervous system, kidney, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "symptoms including vomiting, lethargy, acute hemolytic anemia, renal and liver damage, neurotoxicity, increased blood pressure and respiratory rates" (EHC 200 (1998)), "deaths, probably due to central nervous system depression and hepatic and renal failure, have also been reported," "renal tubular damage was observed" (ATSDR (2004)), and the evidence from animal studies: "acute inflammatory changes were evident in the lungs" (EHC 200 (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, kidney, respiratory system), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "hemolytic anemia was noted," "pathological alterations include pulmonary inflammation, formation of granulomas, fibrohyaline nodules, desquamation of macrophages, and progression of diffuse fibrosis" (ATSDR (2004)). Also based on the evidence from animal studies: "protein droplets in the cytoplasm of cells in the proximal convoluted tubules," "in the kidneys, cytoplasmic protein droplets were evident, and hematological changes indicative of microcytic anemia were observed " (EHC 200 (1998)), "the earliest symptoms of hepatotoxicity are increases in serum chemistry enzymes, particularly alanine aminotransferase" (ATSDR (2004)), "repeated or prolonged exposure to aerosols may result in lung damage" (ICSC (J) (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours LC50=0.00272mg/L of the crustacea (Ceriodaphnia) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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