GHS Classification Result

Chemical Name:Lead diiodide
CAS:10101-63-0

Result:
ID: 304
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable but noninflammable" according to HSDB (2006).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 1g/1,350mL (cold water), Merck (13th, 2001))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing iodine
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID168, Lead, CAS: 7439-92-1," "ID48, Lead Oxide (II); Litharge, CAS: 1317-36-8," and "ID47, Lead Acetate (II), CAS: 301-04-2."
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1987), Category A3 by ACGIH (2001) and Category 2B by Japan Society for Occupational Health.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on expert judgment, given the fact that lead has been known to possess developmental neurotoxic and reproductive toxic potentials in humans. As for the health hazards, refer to "ID168, Lead, CAS: 7439-92-1," "ID48, Lead Oxide (II); Litharge, CAS: 1317-36-8," and "ID47, Lead Acetate (II), CAS: 301-04-2."
8 Specific target organ toxicity - Single exposure Category 1 (blood system, kidney, nervous system) Danger H370: Causes damage to organs (blood system, kidney, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S." (CERI Hazard Data 2001-9 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, kidney, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S." (CERI Hazard Data 2001-9 (2002)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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