GHS Classification Result

Chemical Name：Barium chloride
CAS：10361-37-2

Result：
ID: 310
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 37.0g/100g (25degC), Lide (84th, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing chlorine
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 118mg/kg calculated from the testing data of rat LD50 (oral route) of 118mg/kg (EHC 107 (1990)), 132mg/kg and 220mg/kg (CERI Hazard Data 2001-56 (2002)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on guinea pig skin irritation tests (IUCLID (2000)): "moderately irritating" (though exposure duration not presented).
3 Serious eye damage/eye irritation Classification not possible - - - - The substance is considered to possess a potential for irritation based on the available data on rabbit eye irritation tests. However, classification is not possible in the absence of study detail.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, no positive data on mutagenicity tests in vitro (several indices), described in CICAD 32 (2001) and CERI Hazard Data 2001-56 (2002).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (cardiovascular system, muscle), Category 2 (nervous system), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (cardiovascular system, muscle)
H371: May cause damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence: "the patient suffered vomiting and manifested bigeminal tracings on the ECG," "these symptoms were followed immediately by hypokalemia, progressive paralysis and hypertension," "ventricular contraction abnormalities, prolongation of the QRS interval and marked elevation of the ST segment were detected following 12 hours of administration. An infusion of potassium chloride did not reverse these effects and cardiac arrest eventually occurred 2 hours later," "in both two instances cardiac dysfunction was reported and one patient died due to sudden cardiac arrest" (EHC 107 (1990)), "irritates the eye, skin, respiratory tract; may adversely affect nervous system; may cause hypokalemia; may cause heart/muscle disorder; may lead to death" (ICSC (J) (1999)), "intentional or accidental ingestion of barium compounds causes gastroenteritis (vomiting, diarrhoea, abdominal pain), hypokalemia, cardiac arrhythmias and skeletal muscle paralysis" (CICAD 33 (2001)). Also based on the evidence from animal studies including "somnolency, tetany" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. The priority rating of some studies used for the survey of "epidemiological findings/occupational exposure (human health effects)" is 2, and the effects are classified into Category 1 (cardiovascular system, muscle), Category 2 (nervous system) and Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 1 (heart), Category 2 (kidney, adrenal gland) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (heart)
H373: May cause damage to organs through prolonged or repeated exposure (kidney, adrenal gland) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies: "affected animals exhibited ultrastructural changes in the kidney glomeruli, including basement membrane thickening, epithelial foot process fusion, and the presence of myelin figures," "disturbances in myocardial contractility" (EHC 107 (1990)), "focal hemorrhage in the adrenal" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2. However, the priority rating of some studies used for assessment is 2, and therefore the effects on the kidneys and adrenal are classified into Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=14.5mg/L(Barium Chloride Equivalent: 22.0mg/L) of the crustacea (Daphnia magna) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 5 and bio-accumulation was low (BCF<60 (Existing Chemical Safety Inspections Data)), since it was a metallic compound and the underwater action was unknown, it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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