GHS Classification Result

Chemical Name:Diarsenic pentaoxide
CAS:1303-28-2

Result:
ID: 313
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 65.8g/100mL (20degC), ICSC (2004))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being inorganic compounds containing oxygen. Classified as Division 6.1 (UN#1559) (UN Recommendations on the Transport of Dangerous Goods)
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 8mg/kg (RTECS (2006)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3."
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category K (Arsenic Compounds, Inorganic) by NTP (2005), Group 1 (ARSENIC AND ARSENIC COMPOUNDS) by IARC (1987), Category A1 (Arsenic and inorganic compounds) by ACGIH (2001) and Category 1 (Arsenic and inorganic compounds (as As)) by Japan Society for Occupational Health.
7 Reproductive toxicity Classification not possible - - - - No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3."
8 Specific target organ toxicity - Single exposure Category 1 (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) Danger H370: Causes damage to organs (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence: "acute toxicity of arsenic compounds manifests in humans as symptoms in the gastrointestinal tract and cardiovascular/nervous/blood systems, conjunctivitis and dermatitis along with nasal mucosal/pharyngeal/respiratory irritation, pollakiuria or anuria due to renal tubular blockage by hemoglobin coagulation" (IARC 84 (2004)) and "bone-marrow failure and hepatic hypertrophy" (EHC 224 (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, skin, liver, cardiovascular system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, skin, liver, cardiovascular system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "upper respiratory symptoms such as nasal catarrh, pharyngitis and nasal septum perforation," "respiratory disorder following exposure via drinking water," "pigmentation and keratosis," "cirrhosis," "cardiovascular abnormalities" and "peripheral vascular disorder" (IARC 84 (2004)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96 hours LC50=30.5 mg As/L(Diarsenic Pentoxide Equivalent: 46.8mg/L) of the fish (Morone Saxatilis) (EHC224, 2001).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 3 and it was a metallic compound and an underwater action and bio-accumulation were unknown, it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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