Chemical Name:Diarsenic pentaoxide
CAS:1303-28-2
ID: | 313 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Non-flammable (ICSC, 2004) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (ICSC, 2004) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible (ICSC, 2004) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 65.8g/100mL (20degC), ICSC (2004)) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not classified | - | - | - | - | No data available, though being inorganic compounds containing oxygen. Classified as Division 6.1 (UN#1559) (UN Recommendations on the Transport of Dangerous Goods) |
15 | Organic peroxides | Not applicable | - | - | - | - | Not organic compounds |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 8mg/kg (RTECS (2006)). | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3." |
6 | Carcinogenicity | Category 1A | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category K (Arsenic Compounds, Inorganic) by NTP (2005), Group 1 (ARSENIC AND ARSENIC COMPOUNDS) by IARC (1987), Category A1 (Arsenic and inorganic compounds) by ACGIH (2001) and Category 1 (Arsenic and inorganic compounds (as As)) by Japan Society for Occupational Health. | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3." |
8 | Specific target organ toxicity - Single exposure | Category 1 (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) | Danger | H370: Causes damage to organs (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "acute toxicity of arsenic compounds manifests in humans as symptoms in the gastrointestinal tract and cardiovascular/nervous/blood systems, conjunctivitis and dermatitis along with nasal mucosal/pharyngeal/respiratory irritation, pollakiuria or anuria due to renal tubular blockage by hemoglobin coagulation" (IARC 84 (2004)) and "bone-marrow failure and hepatic hypertrophy" (EHC 224 (2001)). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, skin, liver, cardiovascular system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, skin, liver, cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "upper respiratory symptoms such as nasal catarrh, pharyngitis and nasal septum perforation," "respiratory disorder following exposure via drinking water," "pigmentation and keratosis," "cirrhosis," "cardiovascular abnormalities" and "peripheral vascular disorder" (IARC 84 (2004)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96 hours LC50=30.5 mg As/L(Diarsenic Pentoxide Equivalent: 46.8mg/L) of the fish (Morone Saxatilis) (EHC224, 2001). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 3 and it was a metallic compound and an underwater action and bio-accumulation were unknown, it was classified into Category 3. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |