Chemical Name：tert-Butyl 4-({[(1,3-dimethyl-5-phenoxy-4-pyrazolyl)methylidene]aminooxy}methyl)benzoate; Fenpyroximate
CAS：134098-61-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 245mg/kg (Agricultural Chemical Registration Data (2002)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the absence of mortality at the highest dose of 2,000mg/kg observed in the dermal studies with rats (Agricultural Chemical Registration Data (2002)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation route) value of 0.33mg/L (Agricultural Chemical Registration Data (2002)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (2002)): Non-irritating to the skin.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (2002)): "The substance is a mild eye irritant with reversible effects."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the description in the report on guinea pig skin sensitization tests using the Maximization method: "Caused mild to moderate sensitization" (Agricultural Chemical Registration Data (2002)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutagenicity tests, in vitro chromosome aberration tests and in vivo micronucleus tests on mouse bone marrow cells(Agricultural Chemical Registration Data (1990)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1990).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of reproductive toxicity and teratogenicity in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (1990)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including "soft feces," "eyelid closure," "reduced activity," "laboured breathing" and "lacrimation" were found (Agricultural Chemical Registration Data (2002)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver, kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system, liver, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In rat repeated dose toxicity studies, increased red blood cell counts/volume, increased hemoglobin levels, high platelet counts, and slight hepatocellular hypertrophy were detected (Agricultural Chemical Registration Data (1990)). In dogs, increased urea levels, increased relative liver weight, decreased glycogen in hepatocytes, and cytoplasmic vacuolization of the renal medulla were found. These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.00328mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and rapidly degrading and bio-accumulation were unknown, it was classified into Category 1.