GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Thallium nitrate
CAS：10102-45-1
Result：
| ID: | 327 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | No data available though being nitrates, containing chemical groups with explosive properties. Classified into Divisions 5.1 and 6.1 (UN#2727) (UN Recommendations on the Transport of Dangerous Goods). |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Not classified | - | - | - | - | Classified into Divisions 5.1 and 6.1 (UN#2727) (UN Recommendations on the Transport of Dangerous Goods). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified as oxidizing solids, though being nitrates containing chemical groups with explosive properties. Classified into Divisions 5.1 and 6.1 (UN#2727) (UN Recommendations on the Transport of Dangerous Goods). |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Classified into Divisions 5.1 and 6.1 (UN#2727) (UN Recommendations on the Transport of Dangerous Goods). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 9.55g/100g (20degC), Lide (84th, 2003)) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Category 2 |
|
Danger | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Inorganic compounds containing oxygen and classified as a powerful oxidant according to HSDB (2006). Classified as "Division 5.1: oxidizing substances" by the UN Recommendations on the Transport of Dangerous Goods. However, it can be included in Category 2 or 3, given the fact that it has subsidiary risks corresponding to Division 6.1 and is assigned to Packing Group II (UN#2727). The substance is placed in Category 2 from the viewpoint of safety. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Not organic compounds |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the mouse LD50 (oral route) value of 15mg/kg (RTECS (2004)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on epidemiological studies of human exposure (HSDB (2006)): "The substance severely burns the skin and eye." The substance is thus considered to have corrosive effects. Although classified into Category 1A-1C, it should be placed in Category 1A from the viewpoint of safety if further subclassification is needed. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on epidemiological studies of human exposure (HSDB (2006)): "The substance severely burns the skin and eye." The substance is thus considered to have corrosive effects on the eye. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category D by EPA (1990). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory system, cardiovascular system), Category 2 (kidney, liver) |
|
Danger Warning |
H370: Causes damage to organs (nervous system, respiratory system, cardiovascular system) H371: May cause damage to organs (kidney, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. |
Based on the human evidence: "Lungs showed diffuse alveolar damage. There was extensive damage of the myocardium. Cranial and peripheral neuropathy was observed" (ATSDR (1992)), "temporary lesion of the kidneys and liver, and temporary toxic neuropathy of ocular nerve with subsequent polyneuropathy" (HSDB (2005)). The effects on the kidneys and liver are classified into Category 2 since the priority rating of the referenced study is 2. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, skin, testis), Category 2 (cardiovascular system) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (nervous system, skin, testis) H373: May cause damage to organs through prolonged or repeated exposure (cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence: "Thallium may affect the nervous system following inhalation" (ATSDR 1992), "chief complaints included abdominal pain, fatigue, irritancy, body weight reduction and pain in legs. Four patients had loss of hair" (ACGIH 2001), "clinical symptoms began with excitement and sleeplessness" (PATTY (5th 2001)), "paraesthesias and polyneuritis such as pain in muscles and joints, as well as psychasthenic symptoms such as headache, sleep disorders and fatigue" (EHC 182 (1996)), "may affect the cardiovascular/nervous systems" (IPCS (J) (2002)). Also based on the evidence from animal studies: "thallium caused disturbed behaviour, aggressiveness, diarrhoea, and loss of hair," "Testicular effects including disarrangement of the tubular epithelium, cytoplasmic vacuolization, and distention of the smooth endoplasmic reticulum of Sertoli cells" (EHC 182 (1996)). The effects on the cardiovascular system are classified into Category 2 since the priority rating of the referenced study is 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 24 hours LC50=1142microg/L of the crustacea (Daphnia magna) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 2 and it was a metallic compound and an underwater action and bio-accumulation were unknown, it was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |