GHS Classification Result

Chemical Name:2,2'-Azobisisobutyronitrile
CAS:78-67-1

Result:
ID: 335
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - The substance contains chemical groups associated with explosive properties that contain nitrogen but lack oxygen. The decomposition heat is 1.3kJ/g (Bretherick (J) (5th, 1998)), while SADT stands at 50degC (Studies in Disasters (2002)). These data are not excluded from "explosives," but classification is not possible because of the absence of data. Classified into Division 4.1 (UN#3234) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Type C Danger H242: Heating may cause a fire P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P411: Store at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
Not classified as explosives and "Not applicable" as oxidative solids and organic peroxides; the decomposition heat is 1.3kJ/g (Bretherick (J) (5th, 1998)), while SADT stands at 50degC (Studies in Disasters (2002)) - which correspond to "self-reactive substances." With no data available for classification, the substance is classified into "Type C," according to the classification by UN Recommendations on the Transport of Dangerous Goods: Self-reactive Substance C (Solid) (Thermal Control Required), Class (Category 4.1 Container: No Grade (UN#3234).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 105degC (HSDB, 2005), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) of 100mg/kg (SIDS (2002)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Not classified - - - - Based on the testing data of rabbit skin irritation tests according to OECD Test Guideline 404 (SIDS (2002)), and negative results in human health effects (SIDS (2002)).
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available, though negative results were observed in rabbit eye irritation tests (SIDS (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available, though negative results were observed in animal studies (SIDS (2002)) and human health effects (SIDS (2002)).
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo, described in CERI Hazard Data 2001-45 (2002).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in CERI Hazard Data 2001-45 (2002): Abnormalities in nursing behavior and the death of newborns are observed at dosing levels toxic to dams.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "hypertrophy of centrilobular hepatocytes (the Ministry of Health, Labour and Welfare (1997)). The effects on the liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - According to 72 hours ErC50>7.8mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals (1996)), since the toxicity is not indicated within the upper level concentrations of auxiliary agents, it was classified into Not classified.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although it is water-insolubility and acute toxicity was not reported within the upper level concentrations of the auxiliary agents and there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data), since the bio-accumulation (log Kow=1.1 (PHYSPROP Database (2005))) was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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