Chemical Name：5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3-cyano-4-[(trifluoromethyl)sulfinyl]pyrazole; Fipronil
CAS：120068-37-3

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 97mg/kg (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the absence of mortality at the highest dose of 2,000mg/kg observed in the dermal studies with rats (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation route) value of 0.68mg/L (Agricultural Chemical Registration Data (1995)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests, reported in Agricultural Chemical Registration Data (1995).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit eye irritation tests, mild conjunctival redness was noted with a mean Draize score of 0.44. The reactions resolved by Day 3 (Agricultural Chemical Registration Data (1995)). The substance is thus considered non-irritating.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	Two sensitization studies in guinea pigs using the Maximization method yielded inconsistent results (positive rates of 20% and 0%) (Agricultural Chemical Registration Data (1995, 1996)), which do not allow the presence or absence of sensitization to be determined.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutagenicity tests and chromosome aberration tests, and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1995)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in mouse and rat carcinogenicity studies (Agricultural Chemical Registration Data (1995)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of reduced mating frequency (F1) and reduced numbers of litters/live borns at doses causing reduced body weight gains, observed in rat 2-generation reproduction studies (Agricultural Chemical Registration Data (1995)). Since it cannot be clearly demonstrated that these findings of reproductive effects are secondary, the substance is classified into Category 2 from the viewpoint of safety.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including clonic convulsions, piloerection, abnormal gait, diarrhea, decreased respiration rate, lethargy, coma, tremors and reduced locomotor activity were reported (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system), Category 2 (thyroid, liver)		Danger Warning	H372: Cause damage to organs through prolonged or repeated exposure (nervous system) H373: May cause damage to organs through prolonged or repeated exposure (thyroid, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In rat repeated dose toxicity studies, clinical signs and symptoms including increased absolute/relative weights of the liver and thyroid gland, tendency of the increased incidence of hypertrophy/hyperplasia in thyroid gland cystic epitelial cells, and increased panlobular lipogenesis (males) were found. In dogs, evidence of reduced activity, tremors, convulsions and muscular fasciculations was reported (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 1 (nervous system) and Category 2 (liver and thyroid gland).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from ErC50=0.074mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 1995).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4 (PHYSPROP Database, 2005)), it was classified into Category 1.