GHS Classification Result

Chemical Name:Polymer of 4,4'-isopropylidenediphenol and 1-chloro-2,3-epoxypropane (liquid); Bisphenol A type epoxy resin (liquid)
CAS:25068-38-6

Result:
ID: 354
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though containing a distorted ring structure.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the testing data of rat LD50 (oral route) of 11,400mg/kg representing the lowest fixed value of the testing data, >1,000mg/kg, 11,400mg/kg, and 13,600mg/kg (CERI Hazard Data 2001-36 (2002)).
1 Acute toxicity (Dermal) Classification not possible - - - - No definitive value available, although the substance can be classified as Category 4 or above, based on the rabbit LD50 (dermal route) of >1,600mg/kg (CERI Hazard Data 2001-36 (2002)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" (20degC, 1atm) according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on rabbit primary skin irritation tests (CERI Hazard Data 2001-36 (2002), DFGOT vol.19 (2003)): The substance does not cause or causes moderate irritation to the skin, though the results of 4-hour application are not available. The substance is considered "irritating."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-36 (2002)): The substance does not cause or causes moderate irritation to the eyes. The substance is considered "mildly irritating."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the report on human cases and tests on human volunteers (CERI Hazard Data 2001-36 (2002), DFGOT vol.19 (2003), the results of guinea pig skin sensitization tests and the classification by the Japanese Society of Occupational Allergy (category: skin sensitizing substance). The substance causes skin sensitization.
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on multi-generation mutagenicity tests (dominant lethal tests), germ cell mutagenicity tests in vivo (chromosome aberration tests), and somatic cell mutagenicity tests in vivo (micronucleus tests and chromosome aberration tests), described in DFGOT vol. 19 (2003).
6 Carcinogenicity Classification not possible - - - - Cannot be classified due to lack of existing classification.
7 Reproductive toxicity Not classified - - - - Based on the description in the report on reproductive toxicity and teratogenicity tests (PATTY (4th, 2000), DFGOT vol.19 (2003)): No reproductive and developmental toxicity is observed at dosing levels toxic to parental animals.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since a potential that relevant toxicity was indicated in the water solubility (0.041mg/L(CERI/NITE Hazard Assessment Report (preliminary version) (2006) and others)) of this substance could not be denied from 48 hours EC50=1.7mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (preliminary version) (2006) and others), it was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (BCF<=42(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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