GHS Classification Result

Chemical Name：2,6-Xylenol
CAS：576-26-1

Result：
ID: 369
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" according to HSDB (2005). Classified into Division 6.1 (UN#2261) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2261) (UN Recommendations on the Transport of Dangerous Goods)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 49degC (HSDB, 2004), test temperature:140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#2261) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 296mg/kg (CERI Hazard Data 2001-48 (2002)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 700mg/kg representing the lower of the two testing data, 2,322mg/kg and 700mg/kg (CERI Hazard Data 2001-48 (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on the rabbit and guinea pig skin irritation tests (CERI Hazard Data 2001-48 (2002)): "erythema and ulceration were observed." Also based on the description of human effects: "the substance causes chemical burn and corrosion of the skin and mucosal membranes at the site of contact" (CERI Hazard Data 2001-48 (2002)). Although classified as Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence from rabbit eye irritation tests: "eye irritant" (though the severity of effects is unknown) (IUCLID (2002) and RTECS (2003)). Also based on the human evidence of skin and mucosal corrosion (CERI Hazard Data 2001-48 (2002)), suggesting eye corrosion.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no strong positive data on mutagenicity tests in vitro, described in CERI Hazard Data 2001-48 (2002), NTP DB (Access on October 2005).
6 Carcinogenicity Classification not possible - - - - Cannot be classified given the insufficiency of data for use in classification along with the absence of existing classification.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to the insufficiency of data for use in a comprehensive evaluation of reproductive toxicity, although the available studies show negative results for teratogenic toxicity.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, heart, kidney) Danger H370: Causes damage to organs (nervous system, heart, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "headache, dizziness, nausea, vomiting, muscle twitch, depression of the central nervous system, delirium, loss of consciousness, nausea, vomiting, metabolic acidosis, oliguresis, low blood pressure, heart and kidney damage" (CERI Hazard Data 2001-48 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, liver, spleen) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney, liver, spleen) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "degeneration of the liver, kidney and spleen tissues," "loss of hepatic function including detoxification and excretion" (MOE Risk Assessment vol.3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=11200microg/L of the crustacea (Daphnia magna) (MOE Risk Assessment vol. 3 (2004) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (it was reported that this substance was easy to degrade in the water because (Saint Lawrence River) (CERI Hazard Data (2002)) and the bio-accumulation was low (log Kow=2.36 (PHYSPROP Database (2005))), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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