GHS Classification Result

Chemical Name：Glyoxal
CAS：107-22-2

Result：
ID: 370
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - No data available. Flash point of 40% solution: <=100degC, according to ICSC (2003)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available (boiling point: 50.4degC (Lide, 84th, 2003), test temperature: 55degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 200mg/kg (MOE Risk Assessment vol.2 (2003)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (dermal route) value of 12,700mg/kg (CICAD 57 (2004)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the rat LC50 (4-hour inhalation exposure) value of 2.44mg/L (equivalent to 5,860ppm) (SIDS (2003)) was lower than 90% of the saturated vapour concentration (264,000ppm) under a saturated vapour pressure of 26.7kPa (20degC), the substance is "Not classified."
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the human evidence of "moderate irritation," although the results of animal skin irritation tests indicate "severe irritation" (CERI Hazard Data 98-8 (1999), SIDS (2003)), "mild irritation" (CERI Hazard Data 98-8 (1999), SIDS (2003)), "erythema" (CICADS 57 (2004), "no irritation" (SIDS (2003)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on the rabbit eye irritation tests: "severe irritant" (CERI Hazard Data 98-8 (1999)); "severe erythema and mild edema of the conjunctiva, and inflammation and opacity of the iris were observed. The reactions resolved 1-2 weeks after exposure"; "severe conjunctival erythema/inflammation and iris inflammation/opacity" (SIDS (2003)). The substance is thus considered to cause severe irreversible irritation of the eye.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the positive results in guinea pig skin sensitization tests performed based on the Buehler and Maximization Methods (SIDS (2003) and CERI Hazard Data 98-8 (1999)), and the human epidemiological evidence of "skin necrosis, erythema and edema." The substance is thus considered to cause "skin sensitization."
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo, negative data on somatic cell mutagenicity tests in vivo (micronucleus test), described in CERI Hazard Data 98-8(1999), SIDS (2003), NTP DB (Access on October 2005), CICAD 57 (2004).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as A4 by ACGIH (2001).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, liver, heart, kidney, adrenal gland, nervous system) Warning H371: May cause damage to organs (respiratory system, liver, heart, kidney, adrenal gland, nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "hemorrhage of the lung/liver/heart, congestion of the lung/gastrointestinal tract/adrenal, discoloration of the kidney, mottled discoloration of the liver, coma, piloerection" (SIDS (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "epidermal hyperplasia of pharynx mucosal surface with infiltration of submucosal lymphocytes" (CERI Hazard Data 98-8 (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - Insufficient data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=86mg/L of the fish (Fathead Minnows) (SIDS (2003) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 65% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=-1.66 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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